Flueggethers B-D, Securinega alkaloids with rare oligomerizing pattern from Flueggea virosa
文献类型：期刊论文
| 作者 | Zhang, Hua2; Han, Ying-Shan1; Wainberg, Mark A.1; Yue, Jian-Min2
|
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2016-04-20 |
| 卷号 | 57期号:16页码:1798-1800 |
| 关键词 | Flueggea virosa Flueggether Securinega alkaloid Anti-HIV Alkaloid oligomer |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2016.03.034 |
| 文献子类 | Article |
| 英文摘要 | Three new Securinega alkaloids, flueggethers B and C (1 and 2) as dimers and flueggether D (3) as a trimer, were isolated from the twigs and leaves of a Chinese herb, Flueggea virosa. Their structures were characterized by spectroscopic means and NMR comparison with known analogues. Among all Securinega alkaloid oligomers reported to date, alkaloids 1 and 2 are rare examples linked via an ether bond, while 3 represents the first member with a mixed oligomerizing pattern incorporating both oxygen bridge and carbon-carbon linkage. An in vitro anti-HIV bioassay revealed moderate activity for 3. (C) 2016 Elsevier Ltd. All rights reserved. |
| 资助项目 | National Natural Science Foundation of P. R. China[81322045] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000374082800016 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276072]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 期刊编辑部 新药研究国家重点实验室 分析化学研究室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.McGill Univ, Jewish Gen Hosp, Aids Ctr, Lady Davis Inst Med Res, 3755 Cote Ste Catherine Rd, Montreal, PQ H3T 1E2, Canada 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Hua,Han, Ying-Shan,Wainberg, Mark A.,et al. Flueggethers B-D, Securinega alkaloids with rare oligomerizing pattern from Flueggea virosa[J]. TETRAHEDRON LETTERS,2016,57(16):1798-1800. |
| APA | Zhang, Hua,Han, Ying-Shan,Wainberg, Mark A.,&Yue, Jian-Min.(2016).Flueggethers B-D, Securinega alkaloids with rare oligomerizing pattern from Flueggea virosa.TETRAHEDRON LETTERS,57(16),1798-1800. |
| MLA | Zhang, Hua,et al."Flueggethers B-D, Securinega alkaloids with rare oligomerizing pattern from Flueggea virosa".TETRAHEDRON LETTERS 57.16(2016):1798-1800. |
入库方式： OAI收割
来源：上海药物研究所
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