Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents
文献类型：期刊论文
| 作者 | An, Weiteng; Wang, Wei; Yu, Ting; Zhang, Yongliang; Miao, Zehong; Meng, Tao ; Shen, Jingkang
|
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2016-04-13 |
| 卷号 | 112页码:367-372 |
| 关键词 | Anticancer agents Tubulin inhibitor Intra-molecular hydrogen bonding Colchicine binding site |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2016.02.004 |
| 文献子类 | Article |
| 英文摘要 | A series of 2-aryl-imidazo-pyridines/pyrazines derivatives has been designed, synthesized and evaluated for their biological activities. Among them, several investigated compounds (1a, 3b and 3d) displayed potent antiproliferative activity against HeLa cell, and also displayed comparable tubulin polymerization inhibitory activity to colchicine. These studies provided a new molecular scaffold for the further development of antitumor agents that target tubulin. (C) 2016 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | 3-COMPONENT CONDENSATION ; COMBINATORIAL SYNTHESIS ; ANTICANCER DRUGS ; INHIBITORS ; COLCHICINE ; PYRAZINES ; BINDING |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2012ZX09103-101-026] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2014ZX09508001] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2013ZX09507001] ; National Natural Science Foundation of China[81473130] ; National Natural Science Foundation of China[81473092] ; National Natural Science Foundation of China[81330076] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000372558200030 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276077]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物化学研究室 |
| 通讯作者 | Miao, Zehong; Meng, Tao; Shen, Jingkang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | An, Weiteng,Wang, Wei,Yu, Ting,et al. Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2016,112:367-372. |
| APA | An, Weiteng.,Wang, Wei.,Yu, Ting.,Zhang, Yongliang.,Miao, Zehong.,...&Shen, Jingkang.(2016).Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,112,367-372. |
| MLA | An, Weiteng,et al."Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 112(2016):367-372. |
入库方式： OAI收割
来源：上海药物研究所
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