Structure and Configuration of Phosphoeleganin, a Protein Tyrosine Phosphatase 1B Inhibitor from the Mediterranean Ascidian Sidnyum elegans
文献类型：期刊论文
| 作者 | Imperatore, Concetta2; Luciano, Paolo2; Aiello, Anna2; Vitalone, Rocco2,4; Irace, Carlo3; Santamaria, Rita3; Li, Jia1 ; Guo, Yue-W.1; Menna, Marialuisa2
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2016-04 |
| 卷号 | 79期号:4页码:1144-1148 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.6b00063 |
| 文献子类 | Article |
| 英文摘要 | A new phosphorylated polyketide, phosphoeleganin (1), has been isolated from the Mediterranean ascidian Sidnyum elegans. Its structure and configuration have been determined by extensive use of 2D NMR and microscale chemical degradation and/or derivatization. Phosphoeleganin (1) inhibited the protein tyrosine phosphatase 1B (PTP1B) activity. |
| WOS关键词 | CHIRAL DERIVATIZING AGENTS ; ABSOLUTE-CONFIGURATION ; PD 113,270 ; NMR ; ASSIGNMENT ; ALCOHOLS ; OBESITY ; PHOSLACTOMYCINS ; FERMENTATION ; MANIPULATION |
| 资助项目 | Regione Campania under POR Campania FESR-O.O. 2.1[00000000] ; EU[311848] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000374915800059 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276086]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Menna, Marialuisa |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Zu Chong Zhi Rd 555, Shanghai 201203, Peoples R China; 2.Univ Naples Federico II, Dept Pharm, NeaNat Grp, Via D Montesano 49, I-80131 Naples, Italy; 3.Univ Naples Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy; 4.Axxam Discovery Chem, Via P Castellino 111, I-80100 Naples, Italy |
| 推荐引用方式 GB/T 7714 | Imperatore, Concetta,Luciano, Paolo,Aiello, Anna,et al. Structure and Configuration of Phosphoeleganin, a Protein Tyrosine Phosphatase 1B Inhibitor from the Mediterranean Ascidian Sidnyum elegans[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(4):1144-1148. |
| APA | Imperatore, Concetta.,Luciano, Paolo.,Aiello, Anna.,Vitalone, Rocco.,Irace, Carlo.,...&Menna, Marialuisa.(2016).Structure and Configuration of Phosphoeleganin, a Protein Tyrosine Phosphatase 1B Inhibitor from the Mediterranean Ascidian Sidnyum elegans.JOURNAL OF NATURAL PRODUCTS,79(4),1144-1148. |
| MLA | Imperatore, Concetta,et al."Structure and Configuration of Phosphoeleganin, a Protein Tyrosine Phosphatase 1B Inhibitor from the Mediterranean Ascidian Sidnyum elegans".JOURNAL OF NATURAL PRODUCTS 79.4(2016):1144-1148. |
入库方式： OAI收割
来源：上海药物研究所
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