Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/Chemotherapy of the Drug-Resistant Tumor
文献类型：期刊论文
| 作者 | Wang, Tingting1,2; Wang, Dangge1,2; Yu, Haijun1,2 ; Wang, Mingwei3; Liu, Jianping1,2; Feng, Bing1,2; Zhou, Fangyuan1,2; Yin, Qi1,2; Zhang, Zhiwen1,2; Huang, Yongzhuo1,2
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| 刊名 | ACS NANO
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| 出版日期 | 2016-03 |
| 卷号 | 10期号:3页码:3496-3508 |
| ISSN号 | 1936-0851 |
| 关键词 | acid-switchable micelles drug resistance tissue penetration combinational therapy multimodal imaging |
| DOI | 10.1021/acsnano.5b07706 |
| 文献子类 | Article |
| 英文摘要 | The intrinsic or acquired drug resistance is the main challenge for cancer chemotherapy today. So far, many nanosized drug delivery systems (NDDS) have been exploited to combat cancer drug resistance. However, the therapy efficacy of current NDDS is severely impaired by the limited tumor penetration of the nanoparticles due to the existence of physiological and pathological barriers in the solid tumor. In this study, we report on the design and fabrication of intracellularly acid-switchable multifunctional micelles for combinational photo- and chemotherapy of the drug-resistant tumor. The micelles were composed of a pH-responsive diblock copolymer, a photosensitizer, and a polymeric prodrug of doxorubicin. The micelle displayed silenced fluorescence and photoactivity during the blood circulation and switched to an active state in weakly acid conditions (i.e., pH <= 6.2) in the endocytic vesicles to dramatically induce a 7.5-fold increase of the fluorescence signal for fluorescence imaging. Upon near-infrared (NIR) laser irradiation, the micelle induced notable reactive oxygen species generation to trigger cytosol release of the chemotherapeutics and perform photodynamic therapy (PDT). Moreover, the micelle efficiently converted the MR light to local heat for enhancing tumor penetration of the anticancer drug, tumor specific photothermal therapy, and photoacoustic (PA) imaging. Furthermore, the micelles could generate amplified magnetic resonance (MR) signal in an acidic microenvironment to perform MR imaging. Collectively, this study presents a robust nanoplatform for multimodal imaging and combinational therapy of the drug-resistant tumor, which might provide an insight for developing polymer based NDDS for cancer therapy. |
| WOS关键词 | SIRNA DELIVERY ; CANCER-THERAPY ; POLYMERIC MICELLES ; NANOPARTICLES ; NANOMEDICINE ; TOMOGRAPHY ; NANOMATERIALS ; ACCUMULATION ; THERANOSTICS ; NANOPLATFORM |
| 资助项目 | National Basic Research Program of China[2013CB932704] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81373359] ; National Natural Science Foundation of China[11275050] ; Youth Innovation Promotion Association CAS[00000000] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000372855400052 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276114]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yu, Haijun; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Fudan Univ, Shanghai Canc Ctr, Dept Nucl Med, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Tingting,Wang, Dangge,Yu, Haijun,et al. Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/Chemotherapy of the Drug-Resistant Tumor[J]. ACS NANO,2016,10(3):3496-3508. |
| APA | Wang, Tingting.,Wang, Dangge.,Yu, Haijun.,Wang, Mingwei.,Liu, Jianping.,...&Li, Yaping.(2016).Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/Chemotherapy of the Drug-Resistant Tumor.ACS NANO,10(3),3496-3508. |
| MLA | Wang, Tingting,et al."Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/Chemotherapy of the Drug-Resistant Tumor".ACS NANO 10.3(2016):3496-3508. |
入库方式： OAI收割
来源：上海药物研究所
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