Discovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT(1) Selective Antagonists
文献类型：期刊论文
| 作者 | Chen, Huayan1; Yang, Hui2; Wang, Zhilong2; Xie, Xin2 ; Nan, Fajun1
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| 刊名 | ACS MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2016-03 |
| 卷号 | 7期号:3页码:335-339 |
| 关键词 | Cysteinyl leukotrienes CysLT(1) CysLT(2) selective antagonists asthma |
| ISSN号 | 1948-5875 |
| DOI | 10.1021/acsmedchemlett.5b00482 |
| 文献子类 | Article |
| 英文摘要 | The indole derivative, 34(E)-3-((3-((E)-2-(7-chloroquinolin-2yl)vinyl)phenyl)amino)-3-oxoprop-1-en-1-yl)-7-methoxy-1H-indole-2-carboxylic acid (17k), was identified as a novel and highly potent and selective CysLT(1) antagonist with IC50 values of 0.0059 +/- 0.0011 and 15 +/- 4 mu M for CysLT(1) and CysLT(2), respectively. |
| WOS关键词 | CYSTEINYL-LEUKOTRIENES ; RECEPTOR ; POTENT ; EXPRESSION ; ASTHMA |
| 资助项目 | Ministry of Science and Technology of China[2015CB964503] ; National Natural Science Foundation of China[81425024] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000372042900026 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276119]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xie, Xin; Nan, Fajun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Huayan,Yang, Hui,Wang, Zhilong,et al. Discovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT(1) Selective Antagonists[J]. ACS MEDICINAL CHEMISTRY LETTERS,2016,7(3):335-339. |
| APA | Chen, Huayan,Yang, Hui,Wang, Zhilong,Xie, Xin,&Nan, Fajun.(2016).Discovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT(1) Selective Antagonists.ACS MEDICINAL CHEMISTRY LETTERS,7(3),335-339. |
| MLA | Chen, Huayan,et al."Discovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT(1) Selective Antagonists".ACS MEDICINAL CHEMISTRY LETTERS 7.3(2016):335-339. |
入库方式： OAI收割
来源：上海药物研究所
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