Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells
文献类型：期刊论文
| 作者 | Zhang, Yuanyuan1,2; Wang, Yuqi2; Wei, Youheng2; Wu, Jiaxue2; Zhang, Pingzhao2; Shen, Suqin2; Saiyin, Hexige2; Wumaier, Reziya2; Yang, Xianmei2; Wang, Chenji2 |
| 刊名 | CANCER LETTERS
 |
| 出版日期 | 2016-03-01 |
| 卷号 | 372期号:1页码:101-109 |
| 关键词 | Chaperonin CCT3 Hepatocellular carcinoma Microtubule Vincristine |
| ISSN号 | 0304-3835 |
| DOI | 10.1016/j.canlet.2015.12.029 |
| 文献子类 | Article |
| 英文摘要 | CCT3 was one of the subunits of molecular chaperone CCT/TRiC complex, which plays a central role in maintaining cellular proteostasis. We demonstrated that expressions of CCT3 mRNA and protein are highly up-regulated in hepatocellular carcinoma (HCC) tissues, and high level of CCT3 is correlated with poor survival in cancer patients. In HCC cell lines, CCT3 depletion suppresses cell proliferation by inducing mitotic arrest at prometaphase and apoptosis eventually. We also identified CCT3 as a novel regulator of spindle integrity and as a requirement for proper kinetochore-microtubule attachment during mitosis. Moreover, we found that CCT3 depletion sensitizes HCC cells to microtubule destabilizing drug Vincristine. Collectively, our study suggests that CCT3 is indispensible for HCC cell proliferation, and provides a potential drug target for treatment of HCC. (C) 2015 Elsevier Ireland Ltd. All rights reserved. |
| WOS关键词 | CYTOSOLIC CHAPERONIN ; CYTOSKELETAL ORGANIZATION ; CYTOPLASMIC CHAPERONIN ; CYCLE PROGRESSION ; COMPLEX ; TUBULIN ; CANCER ; EXPRESSION ; SUBUNITS ; TARGET |
| 资助项目 | National Natural Science Foundation of China[81472567] ; National Natural Science Foundation of China[31301202] ; National Natural Science Foundation of China[81171964] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000370832600011 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276129]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Chenji; Yu, Long |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Fudan Univ, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci, 2005 Songhu Rd, Shanghai 200433, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Yuanyuan,Wang, Yuqi,Wei, Youheng,et al. Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells[J]. CANCER LETTERS,2016,372(1):101-109. |
| APA | Zhang, Yuanyuan.,Wang, Yuqi.,Wei, Youheng.,Wu, Jiaxue.,Zhang, Pingzhao.,...&Yu, Long.(2016).Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells.CANCER LETTERS,372(1),101-109. |
| MLA | Zhang, Yuanyuan,et al."Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells".CANCER LETTERS 372.1(2016):101-109. |
入库方式： OAI收割
来源：上海药物研究所
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