pH-Responsive Wormlike Micelles with Sequential Metastasis Targeting Inhibit Lung Metastasis of Breast Cancer
文献类型：期刊论文
| 作者 | He, Xinyu1,2; Yu, Haijun1,2 ; Bao, Xiaoyue1,2; Cao, Haiqiang1,2; Yin, Qi1,2; Zhang, Zhiwen1,2; Li, Yaping1,2
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| 刊名 | ADVANCED HEALTHCARE MATERIALS
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| 出版日期 | 2016-02-18 |
| 卷号 | 5期号:4页码:439-448 |
| 关键词 | micelles pH-responsive sequential targeting lung metastasis breast cancer |
| ISSN号 | 2192-2640 |
| DOI | 10.1002/adhm.201500626 |
| 文献子类 | Article |
| 英文摘要 | Cancer metastasis is the main cause for the high mortality in breast cancer patients. Herein, we first report succinobucol-loaded pH-responsive wormlike micelles (PWMs) with sequential targeting capability to inhibit lung metastasis of breast cancer. PWMs can in a first step be delivered specifically to the sites of metastases in the lungs and then enable the intracellular pH-stimulus responsive drug release in cancer cells to improve the anti-metastatic effect. PWMs are identified as nanofibrillar assemblies with a diameter of 19.9 +/- 1.9 nm and a length within the 50-200 nm range, and exhibited pH-sensitive drug release behavior in response to acidic intracellular environments. Moreover, PWMs can obviously inhibit the migration and invasion abilities of metastatic 4T1 breast cancer cells, and reduce the expression of the metastasis-associated vascular cell adhesion molecule-1 (VCAM-1) at 400 ng mL(-1) of succinobucol. In particular, PWMs can induce a higher specific accumulation in lung and be specifically delivered to the sites of metastases in lung, thereby leading to an 86.6% inhibition on lung metastasis of breast cancer. Therefore, the use of sequentially targeting PWMs can become an encouraging strategy for specific targeting and effective treatment of cancer metastasis. |
| WOS关键词 | SELF-ASSEMBLED NANOPARTICLES ; DRUG-DELIVERY ; CELLULAR INTERNALIZATION ; POLYMERIC NANOPARTICLES ; PARTICLE DESIGN ; IN-VIVO ; SHAPE ; SIZE ; VCAM-1 ; PENETRATION |
| 资助项目 | National Basic Research Program of China[2015CB932103] ; National Basic Research Program of China[2013CB932503] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81373359] ; K.C. Wong Education Foundation[00000000] |
| WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000371097100008 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276142]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Zhiwen; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Xinyu,Yu, Haijun,Bao, Xiaoyue,et al. pH-Responsive Wormlike Micelles with Sequential Metastasis Targeting Inhibit Lung Metastasis of Breast Cancer[J]. ADVANCED HEALTHCARE MATERIALS,2016,5(4):439-448. |
| APA | He, Xinyu.,Yu, Haijun.,Bao, Xiaoyue.,Cao, Haiqiang.,Yin, Qi.,...&Li, Yaping.(2016).pH-Responsive Wormlike Micelles with Sequential Metastasis Targeting Inhibit Lung Metastasis of Breast Cancer.ADVANCED HEALTHCARE MATERIALS,5(4),439-448. |
| MLA | He, Xinyu,et al."pH-Responsive Wormlike Micelles with Sequential Metastasis Targeting Inhibit Lung Metastasis of Breast Cancer".ADVANCED HEALTHCARE MATERIALS 5.4(2016):439-448. |
入库方式： OAI收割
来源：上海药物研究所
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