A new bioactive steroidal ketone from the South China Sea sponge Xestospongia testudinaria
文献类型：期刊论文
| 作者 | He, Wen-Fei1,2; Xue, Duo-Qing1; Yao, Li-Gong1; Li, Jia1 ; Liu, Hai-Li1; Guo, Yue-Wei1
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| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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| 出版日期 | 2016-02-01 |
| 卷号 | 18期号:2页码:195-199 |
| 关键词 | PTP1B inhibitory activity Xestospongia testudinaria sponge Petrosiidae steroidal ketone |
| ISSN号 | 1028-6020 |
| DOI | 10.1080/10286020.2015.1056521 |
| 文献子类 | Article |
| 英文摘要 | A new steroidal ketone (1), with an ergosta-22,25-diene side chain, was obtained from the South China Sea marine sponge Xestospongia testudinaria. The structure of 1 was determined on the basis of detailed spectroscopic analysis and by comparison with literature. Compound 1 exhibited significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a key target for the treatment of type II diabetes and obesity, with an IC50 value of 4.27 +/- 0.55 mu M, which is comparable with the positive control oleanolic acid (IC50=2.63 +/- 0.22 mu M). |
| WOS关键词 | BROMINATED POLYUNSATURATED LIPIDS ; MARINE SPONGE ; SOFT CORAL ; SARCOPHYTON SP ; INHIBITORS ; ALKALOIDS ; STEROLS ; ACIDS |
| 资助项目 | Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[41306130] ; Natural Science Foundation of China[81302692] ; Natural Science Foundation of China[41476063] ; National Marine '863' Project[2012AA092105] ; National Marine '863' Project[2013AA092902] ; China Postdoctoral Science Foundation[2012M520956] ; China Postdoctoral Science Foundation[2014T70443] ; SCTSM Project[14431901100] ; EU 7th Framework Programme-IRSES Project[246987] |
| WOS研究方向 | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000371344000011 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276156]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hai-Li; Guo, Yue-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China; |
| 推荐引用方式 GB/T 7714 | He, Wen-Fei,Xue, Duo-Qing,Yao, Li-Gong,et al. A new bioactive steroidal ketone from the South China Sea sponge Xestospongia testudinaria[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2016,18(2):195-199. |
| APA | He, Wen-Fei,Xue, Duo-Qing,Yao, Li-Gong,Li, Jia,Liu, Hai-Li,&Guo, Yue-Wei.(2016).A new bioactive steroidal ketone from the South China Sea sponge Xestospongia testudinaria.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,18(2),195-199. |
| MLA | He, Wen-Fei,et al."A new bioactive steroidal ketone from the South China Sea sponge Xestospongia testudinaria".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 18.2(2016):195-199. |
入库方式： OAI收割
来源：上海药物研究所
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