ent-6,7-Secokaurane diterpenoids from Rabdosia serra and their cytotoxic activities
文献类型：期刊论文
| 作者 | Wang, Wen-qiong; Xuan, Li-jiang
|
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2016-02 |
| 卷号 | 122页码:119-125 |
| 关键词 | Rabdosia serra Lamiaceae ent-Kaurane diterpenoids Cytotoxic activity |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2015.11.014 |
| 文献子类 | Article |
| 英文摘要 | Investigation of the hydrophobic extract of Rabdosia serra (Lamiaceae) led to the isolation of seven ent-6,7-secokaurane diterpenoids rabdosins E-K, along with twelve known ent-kaurane diterpenoids. Their structures were established by extensive spectroscopic analysis. The absolute configurations of rabdosins E, F, H and I were determined by single -crystal X-ray diffraction, with rabdosin E having a 3,20 -epoxy group. These diterpenoids could be divided into two types according to their skeletons: rabdoMns E -J are ent-6,20-epoxy-6,7-secokaur-1,7-olides, and rabdosin K is an ent-6,7-secokaur-7,20-olide. Cytotoxicity evaluation showed that serrin B, serrin A, isodocarpin and lushanrubescensin J exhibited weak to moderate cytotoxic activities (IC50 < 10 mu M) against two human cancer cell lines. (C) 2015 Elsevier Ltd. All rights reserved. |
| WOS关键词 | RUBESCENS VAR. LUSHANENSIS ; ENT-KAURENE DITERPENOIDS ; ABSOLUTE-CONFIGURATION ; KAURANE DITERPENOIDS ; JAPONICUS HARA ; ISODON-SERRA ; CONSTITUENTS ; TERPENOIDS |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09301-001] ; National Natural Sciences Foundation of China[30901851] ; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences[SIMM0907 KF-04] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000369460200012 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276165]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Xuan, Li-jiang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Wen-qiong,Xuan, Li-jiang. ent-6,7-Secokaurane diterpenoids from Rabdosia serra and their cytotoxic activities[J]. PHYTOCHEMISTRY,2016,122:119-125. |
| APA | Wang, Wen-qiong,&Xuan, Li-jiang.(2016).ent-6,7-Secokaurane diterpenoids from Rabdosia serra and their cytotoxic activities.PHYTOCHEMISTRY,122,119-125. |
| MLA | Wang, Wen-qiong,et al."ent-6,7-Secokaurane diterpenoids from Rabdosia serra and their cytotoxic activities".PHYTOCHEMISTRY 122(2016):119-125. |
入库方式： OAI收割
来源：上海药物研究所
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