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Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity

文献类型：期刊论文

作者Zhang, Li2; Jiang, Cheng-Shi1,2; Gao, Li-Xin2; Gong, Jing-Xu2; Wang, Zhong-Hua3; Li, Jing-Ya2; Li, Jia2; Li, Xu-Wen2; Guo, Yue-Wei2
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
出版日期2016-02-01
卷号26期号:3页码:778-781
关键词Phidianidine Oxadiazole derivative PTP1B inhibitor Specific selectivity Docking analysis Function-oriented synthesis
ISSN号0960-894X
DOI10.1016/j.bmcl.2015.12.097
文献子类Article
英文摘要A series of phidianidine B derivatives were synthesized by introducing various heterocyclic rings. Their inhibitory effects on PTP1B and other PTPs (TCPTP, SHP1, SHP2 and LAR) were evaluated. A majority of them displayed significant inhibitory potency and specific selectivity over PTP1B. The SAR and molecular docking analysis were also described. (C) 2015 Elsevier Ltd. All rights reserved.
WOS关键词PROTEIN-TYROSINE-PHOSPHATASE ; BIOLOGICAL EVALUATION ; INSULIN SENSITIVITY ; INDOLE ALKALOIDS ; 1B INHIBITORS ; RESISTANCE ; MICE
资助项目National Marine "863" Projects[2013AA092902] ; National Marine "863" Projects[2012AA092105] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[81302692] ; Natural Science Foundation of China[41476063] ; SCTSM Project[15431901000] ; SCTSM Project[14431901100] ; NSFC Shandong Joint Fund for Marine Science Research Centers[U1406402] ; SKLDR/SIMM Projects[SIMM1501ZZ-03] ; SKLDR/SIMM Projects[CASIMM0120152039] ; "Youth Innovation Promotion Association" from Chinese Academy of Sciences[00000000] ; "Young Talent Supporting Project" from China Association for Science and Technology[00000000]
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000368797600016
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/276168]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Li, Xu-Wen; Guo, Yue-Wei
作者单位1.Univ Jinan, Sch Biol Sci & Technol, 336 Nan Xin Zhuang Xi Rd, Jinan 250022, Shandong, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China;
3.Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Hai Quan Rd, Shanghai 201418, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Li,Jiang, Cheng-Shi,Gao, Li-Xin,et al. Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(3):778-781.
APA Zhang, Li.,Jiang, Cheng-Shi.,Gao, Li-Xin.,Gong, Jing-Xu.,Wang, Zhong-Hua.,...&Guo, Yue-Wei.(2016).Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(3),778-781.
MLA Zhang, Li,et al."Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.3(2016):778-781.

入库方式： OAI收割

来源：上海药物研究所

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