Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain
文献类型：期刊论文
| 作者 | Ling, Chen-Yu1; Tao, Yun-Liang2; Chu, Wen-Jing1; Wang, Hui3; Wang, Hai-Dong2; Yang, Yu-She1
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| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2016-02 |
| 卷号 | 27期号:2页码:235-240 |
| 关键词 | Multi-drug resistant bacteria Pleuromutilin 4H-Pyran-4-one Antibacterial activity |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclei.2015.09.019 |
| 文献子类 | Article |
| 英文摘要 | A series of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain have been designed and synthesized. In vitro antibacterial activity evaluation showed that most of the derivatives exhibited potent antibacterial activity against drug resistant Gram-positive strains. Compounds 12a, 12d, and 28 are the most active derivatives in this series, displaying activity comparable to that of retapamulin and BC-3781. As the metabolic stability of this series is not satisfactory, further modifications are going on to improve their pharmacokinetic profile. (C) 2015 Chinese Chemical Society and Institute of Materia Medics, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| WOS关键词 | INFECTIOUS-DISEASES SOCIETY ; AMERICA ; AGENTS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5667511 |
| WOS记录号 | WOS:000396297800011 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276171]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Hai-Dong; Yang, Yu-She |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Changzhou Univ, Sch Petrochem Engn, Changzhou 213164, Peoples R China; 3.China Pharmaceut Univ, Dept Microbiol, Nanjing 210009, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ling, Chen-Yu,Tao, Yun-Liang,Chu, Wen-Jing,et al. Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain[J]. CHINESE CHEMICAL LETTERS,2016,27(2):235-240. |
| APA | Ling, Chen-Yu,Tao, Yun-Liang,Chu, Wen-Jing,Wang, Hui,Wang, Hai-Dong,&Yang, Yu-She.(2016).Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain.CHINESE CHEMICAL LETTERS,27(2),235-240. |
| MLA | Ling, Chen-Yu,et al."Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain".CHINESE CHEMICAL LETTERS 27.2(2016):235-240. |
入库方式： OAI收割
来源：上海药物研究所
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