Novel dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs): synthesis and antitumor activities
文献类型：期刊论文
| 作者 | Liu, Gang2; Song, Shanshan3; Liu, Xiaohua2; Zhang, Ao1,2 ; Miao, Zehong1,3; Ding, Chunyong2
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:101页码:98975-98984 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c6ra17323c |
| 文献子类 | Article |
| 英文摘要 | Two new series of dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs) were designed and synthesized though a 1,3-dipolar cycloaddition. Subsequent pharmacological screening led to several compounds having dramatically improved antiproliferative effects against several human tumor cell lines compared to artemisinin and dihydroartemisinin. Mechanistic studies on the most potent artemalogs were investigated. |
| WOS关键词 | VITRO ANTIPLASMODIAL ACTIVITY ; HUMAN LEUKEMIA-CELLS ; PLASMODIUM-FALCIPARUM ; ANTIMALARIAL-DRUGS ; NATURAL-PRODUCTS ; MULTIDRUG-RESISTANCE ; DERIVATIVES ; CYTOTOXICITY ; AGENTS ; DESIGN |
| 资助项目 | Pujiang Talent Project from Shanghai Commission of Science and Technology[14PJ1410700] ; Chinese NSF[81402790] ; Chinese NSF[81125021] ; Chinese NSF[81373277] ; Chinese NSF[81430080] ; National Program on Key Basic Research Project of China[2015CB910603-004] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000387427800051 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276194]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物化学研究室 |
| 通讯作者 | Miao, Zehong; Ding, Chunyong |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Synthet Organ & Med Chem Lab, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liu, Gang,Song, Shanshan,Liu, Xiaohua,et al. Novel dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs): synthesis and antitumor activities[J]. RSC ADVANCES,2016,6(101):98975-98984. |
| APA | Liu, Gang,Song, Shanshan,Liu, Xiaohua,Zhang, Ao,Miao, Zehong,&Ding, Chunyong.(2016).Novel dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs): synthesis and antitumor activities.RSC ADVANCES,6(101),98975-98984. |
| MLA | Liu, Gang,et al."Novel dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs): synthesis and antitumor activities".RSC ADVANCES 6.101(2016):98975-98984. |
入库方式： OAI收割
来源：上海药物研究所
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