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Synthesis, spectral characterization, and antituberculosis activity of thiazino[3,2-A]benzimidazole derivatives

文献类型：期刊论文

作者Gong, Jing-Xu1; He, Ya2; Cui, Zhen-Lin2; Guo, Yue-Wei1
刊名PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
出版日期2016
卷号191期号:7页码:1036-1041
关键词Thiazino-benzimidazole derivatives synthesis crystal structure anti-TB activity
ISSN号1042-6507
DOI10.1080/10426507.2015.1135149
文献子类Article
英文摘要A series of novel thiazino[3,2-a]benzimidazole derivatives synthesized by cyclization of (R)-2-(chloromethyl)oxirane with benzimidazole-2-thiol followed by reacted with benzyl bromides in high yield under milder conditions. The molecular structures of all compounds were confirmed by H-1 and C-13 NMR spectroscopy and Mass spectrometry. The absolute configuration of the compounds was confirmed by X-ray diffraction analysis. All the synthesized compounds were evaluated in vitro for their antituberculosis activity. [GRAPHICS]
WOS关键词BENZIMIDAZOLE DERIVATIVES ; TUBERCULOSIS ; AGENTS
资助项目Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[41306130] ; Natural Science Foundation of China[41506187] ; Natural Science Foundation of China[81302692] ; Natural Science Foundation of China[41476063] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1406402] ; SCTSM Project[14431901100] ; SCTSM Project[15431901000] ; SKLDR/SIMM Projects[CASIMM0120152039] ; SKLDR/SIMM Projects[SIMM1501ZZ-03]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000380942400013
出版者TAYLOR & FRANCIS LTD
源URL[http://119.78.100.183/handle/2S10ELR8/276211]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者He, Ya; Guo, Yue-Wei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.Tongji Univ, Shanghai Pulm Hosp, Sch Med, Clin & Res Ctr TB,Shanghai Key Lab TB, Shanghai 200433, Peoples R China
推荐引用方式
GB/T 7714		 Gong, Jing-Xu,He, Ya,Cui, Zhen-Lin,et al. Synthesis, spectral characterization, and antituberculosis activity of thiazino[3,2-A]benzimidazole derivatives[J]. PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS,2016,191(7):1036-1041.
APA Gong, Jing-Xu,He, Ya,Cui, Zhen-Lin,&Guo, Yue-Wei.(2016).Synthesis, spectral characterization, and antituberculosis activity of thiazino[3,2-A]benzimidazole derivatives.PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS,191(7),1036-1041.
MLA Gong, Jing-Xu,et al."Synthesis, spectral characterization, and antituberculosis activity of thiazino[3,2-A]benzimidazole derivatives".PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS 191.7(2016):1036-1041.

入库方式： OAI收割

来源：上海药物研究所

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