Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects
文献类型：期刊论文
| 作者 | Hu, Chang-Ling2; Xiong, Juan2; Gao, Li-Xin3; Li, Jia3 ; Zeng, Huaqiang1; Zou, Yike4; Hu, Jin-Feng2
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:65页码:60467-60478 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c6ra08986k |
| 文献子类 | Article |
| 英文摘要 | Rare and endangered plants have proven to be better sources for drug discovery than other botanic sources. Pinus dabeshanensis is an endangered plant listed in the China Plant Red Data Book, and has never been phytochemically investigated. In the present study, 11 new (dabeshanensins A-K, 1-11, resp.) and 28 related known naturally occurring diterpenoids were isolated from the shed trunk bark of this plant. The new structures were established by extensive spectroscopic methods and molecular modeling. Among them, dabeshanensin C (3) has an unprecedented bicyclo[3.3.1] nonane ring system (rings B and C) by oxidative cleavage of the C-6/C-7 bond followed by the formation of a new C-C bond between C-6 and C-12. The plausible biosynthetic pathway to 3 is briefly discussed. Dabeshanensins A (1) and J (10), 12-hydroxydehydroabietic acid (33), abieta-8,11,13,15-tetraen-18-oic acid (35), and 15-hydroxy-7-oxo-8,11,13-abietatrien-18-oic acid (37) showed significant inhibitory effects against the human protein tyrosine phosphatase 1B (PTP1B) enzyme, a key target for the treatment of type-II diabetes and obesity, with IC50 values ranging from 5.4 to 50.9 mu M. |
| WOS关键词 | TYROSINE-PHOSPHATASE 1B ; ARALIA-CONTINENTALIS ROOTS ; LARIX KAEMPFERI ; ABIES-GEORGEI ; ABIETANE-TYPE ; CONSTITUENTS ; LEAVES ; BIODIVERSITY ; METABOLITES ; HEARTWOOD |
| 资助项目 | NSFC[21472021] ; NSFC[81273401] ; NSFC[81202420] ; National Basic Research Program of China (973 Program)[2013CB530700] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000379351600066 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276214]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Hu, Jin-Feng |
| 作者单位 | 1.Inst Bioengn & Nanotechnol, 31 Biopolis Way, The Nanos 138669, Singapore; 2.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 4.Univ Penn, Dept Chem, 231 South 34 St, Philadelphia, PA 19104 USA |
| 推荐引用方式 GB/T 7714 | Hu, Chang-Ling,Xiong, Juan,Gao, Li-Xin,et al. Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects[J]. RSC ADVANCES,2016,6(65):60467-60478. |
| APA | Hu, Chang-Ling.,Xiong, Juan.,Gao, Li-Xin.,Li, Jia.,Zeng, Huaqiang.,...&Hu, Jin-Feng.(2016).Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects.RSC ADVANCES,6(65),60467-60478. |
| MLA | Hu, Chang-Ling,et al."Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects".RSC ADVANCES 6.65(2016):60467-60478. |
入库方式： OAI收割
来源：上海药物研究所
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