A pH-Responsive Host-guest Nanosystem Loading Succinobucol Suppresses Lung Metastasis of Breast Cancer
文献类型：期刊论文
| 作者 | Dan, Zhaoling1,2,3; Cao, Haiqiang1,2; He, Xinyu1,2; Zhang, Zhiwen1,2 ; Zou, Lili3; Zeng, Lijuan4; Xu, Yan3; Yin, Qi1,2; Xu, Minghua1,2; Zhong, Dafang1,2
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| 刊名 | THERANOSTICS
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:3页码:435-445 |
| 关键词 | Host-guest nanosystem pH-responsive Cyclodextrin Cancer metastasis Breast cancer |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.13896 |
| 文献子类 | Article |
| 英文摘要 | Cancer metastasis is the leading reason for the high mortality of breast cancer. Herein, we report on a pH-responsive host-guest nanosystem of succinobucol (PHN) with pH-stimuli controlled drug release behavior to improve the therapeutic efficacy on lung metastasis of breast cancer. PHN was composed of the host polymer of beta-cyclodextrin linked with multiple arms of N,N-diisopropylethylenediamine (beta CD-DPA), the guest polymer of adamantyl end-capped methoxy poly(ethylene glycol) (mPEG-Ad), and the active agent of succinobucol. PHN comprises nanometer-sized homogenous spherical particles, and exhibits specific and rapid drug release in response to the intracellular acidic pH-stimuli. Then, the anti-metastatic efficacy of PHN is measured in metastatic 4T1 breast cancer cells, which effectively confirms the superior inhibitory effects on cell migration and invasion activities, VCAM-1 expression and cell-cell binding of RAW 264.7 to 4T1 cells. Moreover, PHN can be specifically delivered to the sites of metastatic nodules in lungs, and result in an obviously improved therapeutic efficacy on lung metastasis of breast cancer. Thereby, the pH-responsive host-guest nanosystem can be a promising drug delivery platform for effective treatment of cancer metastasis. |
| WOS关键词 | MESOPOROUS SILICA NANOPARTICLES ; DRUG-DELIVERY ; GENE DELIVERY ; CYCLODEXTRIN ; THERAPY ; DOXORUBICIN ; SYSTEMS ; TUMORS ; VCAM-1 ; SIRNA |
| 资助项目 | National Basic Research Program of China[2015CB932103] ; National Basic Research Program of China[2013CB932503] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81521005] ; K.C. Wong Education Foundation[00000000] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000377797200012 |
| 出版者 | IVYSPRING INT PUBL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276222]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Zhiwen; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China; 4.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dan, Zhaoling,Cao, Haiqiang,He, Xinyu,et al. A pH-Responsive Host-guest Nanosystem Loading Succinobucol Suppresses Lung Metastasis of Breast Cancer[J]. THERANOSTICS,2016,6(3):435-445. |
| APA | Dan, Zhaoling.,Cao, Haiqiang.,He, Xinyu.,Zhang, Zhiwen.,Zou, Lili.,...&Li, Yaping.(2016).A pH-Responsive Host-guest Nanosystem Loading Succinobucol Suppresses Lung Metastasis of Breast Cancer.THERANOSTICS,6(3),435-445. |
| MLA | Dan, Zhaoling,et al."A pH-Responsive Host-guest Nanosystem Loading Succinobucol Suppresses Lung Metastasis of Breast Cancer".THERANOSTICS 6.3(2016):435-445. |
入库方式： OAI收割
来源：上海药物研究所
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