Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer
文献类型：期刊论文
| 作者 | Zhou, Fangyuan1,2,3; Feng, Bing1,2; Yu, Haijun1,2 ; Wang, Dangge1,2; Wang, Tingting1,2; Liu, Jianping1,2; Meng, Qingshuo1,2; Wang, Siling3; Zhang, Pengcheng1,2; Zhang, Zhiwen1,2
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| 刊名 | THERANOSTICS
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:5页码:679-687 |
| 关键词 | Theranostic Nanomedicine Gold Nanoclusters Fluorescence Imaging Targeted Therapy |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.14556 |
| 文献子类 | Article |
| 英文摘要 | Theranostic nanomedicine has emerged as a promising modality for cancer diagnosis and treatment. In this study, we report the fabrication of fluorescence gold nanoclusters (GNC) conjugated with a cisplatin prodrug and folic acid (FA) (FA-GNC-Pt) for fluorescence imaging and targeted chemotherapy of breast cancer. The physio-chemical properties of FA-GNC-Pt nanoparticles are thoroughly characterized by fluorescence/UV-Vis spectroscopic measurement, particle size and zeta-potential examination. We find that FA-modification significantly accelerated the cellular uptake and increased the cytotoxicity of GNC-Pt nanoparticles in murine 4T1 breast cancer cells. Fluorescence imaging in vivo using 4T1 tumor bearing nude mouse model shows that FA-GNC-Pt nanoparticles selectively accumulate in the orthotopic 4T1 tumor and generate strong fluorescence signal due to the tumor targeting effect of FA. Moreover, we demonstrate that FA-GNC-Pt nanoparticles significantly inhibit the growth and lung metastasis of the orthotopically implanted 4T1 breast tumors. All these data imply a good potential of the GNC-based theranostic nanoplatform for fluorescence tumor imaging and cancer therapy. |
| WOS关键词 | DRUG-DELIVERY SYSTEMS ; POLYMERIC MICELLES ; RENAL CLEARANCE ; AU CLUSTERS ; NANOPARTICLES ; NANORODS ; RADIOTHERAPY ; PENETRATION ; COMBINATION ; AGENTS |
| 资助项目 | National Basic Research Program of China[2013CB932704] ; National Natural Science Foundation of China[81373359] ; National Natural Science Foundation of China[81521005] ; Youth Innovation Promotion Association CAS[00000000] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000377798200006 |
| 出版者 | IVYSPRING INT PUBL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276223]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yu, Haijun; Wang, Siling; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 3.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Fangyuan,Feng, Bing,Yu, Haijun,et al. Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer[J]. THERANOSTICS,2016,6(5):679-687. |
| APA | Zhou, Fangyuan.,Feng, Bing.,Yu, Haijun.,Wang, Dangge.,Wang, Tingting.,...&Li, Yaping.(2016).Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer.THERANOSTICS,6(5),679-687. |
| MLA | Zhou, Fangyuan,et al."Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer".THERANOSTICS 6.5(2016):679-687. |
入库方式： OAI收割
来源：上海药物研究所
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