A facile and efficient method for the synthesis of alkynone by carbonylative Sonogashira coupling using CHCl3 as the CO source
文献类型：期刊论文
| 作者 | Sun, Guanglong; Lei, Min ; Hu, Lihong
|
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:34页码:28442-28446 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c6ra02424f |
| 文献子类 | Article |
| 英文摘要 | A facile and efficient method for the synthesis of alkynones by a Pd-catalyzed carbonylative Sonogashira coupling reaction starting from aryl iodide, terminal alkyne and chloroform (CHCl3) as the CO source is described. This procedure proves that CHCl3 is a cheap and efficient CO source in the presence of CsOH center dot H2O as the base. Furthermore, it is applied successfully for themodification of natural products, such as vindoline and tabersonin, to obtain the corresponding products in good yields. |
| WOS关键词 | PALLADIUM-CATALYZED CARBONYLATION ; 3-COMPONENT PYRIMIDINE SYNTHESIS ; EX-SITU GENERATION ; ONE-POT SYNTHESIS ; 2,5-DISUBSTITUTED FURANS ; ROOM-TEMPERATURE ; TERMINAL ALKYNES ; ACID-CHLORIDES ; KETONES ; YNONES |
| 资助项目 | National Natural Science Foundation of China[81273397] ; National Natural Science Foundation of China[81561148011] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09508104] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000372610200033 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276237]  |
| 专题 | 上海中药现代化研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Lei, Min; Hu, Lihong |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Guanglong,Lei, Min,Hu, Lihong. A facile and efficient method for the synthesis of alkynone by carbonylative Sonogashira coupling using CHCl3 as the CO source[J]. RSC ADVANCES,2016,6(34):28442-28446. |
| APA | Sun, Guanglong,Lei, Min,&Hu, Lihong.(2016).A facile and efficient method for the synthesis of alkynone by carbonylative Sonogashira coupling using CHCl3 as the CO source.RSC ADVANCES,6(34),28442-28446. |
| MLA | Sun, Guanglong,et al."A facile and efficient method for the synthesis of alkynone by carbonylative Sonogashira coupling using CHCl3 as the CO source".RSC ADVANCES 6.34(2016):28442-28446. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。