Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia
文献类型：期刊论文
| 作者 | Zhang, Hua1; Liu, Jia1 ; Gan, Li-She2; Dalal, Seema3,4; Cassera, Maria B.3,4; Yue, Jian-Min1
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
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| 出版日期 | 2016 |
| 卷号 | 14期号:3页码:957-962 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c5ob02296g |
| 文献子类 | Article |
| 英文摘要 | Chemical investigation into the minor constituents of Aphanamixis grandifolia yielded three new diterpenoid dimers, aphadilactones E-G (1-3) featuring a new carbon skeleton. Their structures and absolute configurations were fully established by comprehensive spectroscopic data analysis and ECD calculation. Discovery of another two new dimers (4 and 5) suggested the structure of recently reported aphanamene A to be re-investigated. Compounds 1-5 showed moderate antimalarial activities with low micromolar IC50 values. |
| WOS关键词 | APHADILACTONES A-D ; STEM BARKS ; CHEMICAL-CONSTITUENTS ; FRUITS ; TRITERPENOIDS ; DERIVATIVES ; LIMONOIDS ; RING |
| 资助项目 | National Natural Science Foundation of P. R. China[81322045] ; National Natural Science Foundation of P. R. China[81321092] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000368687600020 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276260]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 期刊编辑部 新药研究国家重点实验室 分析化学研究室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 2.Zhejiang Univ, Inst Modern Chinese Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China; 3.Virginia Polytech Inst & State Univ, Dept Biochem, Blacksburg, VA 24061 USA; 4.Virginia Polytech Inst & State Univ, Virginia Tech, Ctr Drug Discovery, MC 0308, Blacksburg, VA 24061 USA |
| 推荐引用方式 GB/T 7714 | Zhang, Hua,Liu, Jia,Gan, Li-She,et al. Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2016,14(3):957-962. |
| APA | Zhang, Hua,Liu, Jia,Gan, Li-She,Dalal, Seema,Cassera, Maria B.,&Yue, Jian-Min.(2016).Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia.ORGANIC & BIOMOLECULAR CHEMISTRY,14(3),957-962. |
| MLA | Zhang, Hua,et al."Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia".ORGANIC & BIOMOLECULAR CHEMISTRY 14.3(2016):957-962. |
入库方式： OAI收割
来源：上海药物研究所
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