Bioactive isoquinolinequinone alkaloids from the South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp.
文献类型：期刊论文
| 作者 | Huang, Ren-Yong1; Chen, Wen-Ting1; Kurtan, Tibor2; Mandi, Attila2; Ding, Jian1 ; Li, Jia1; Li, Xu-Wen1; Guo, Yue-Wei1
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| 刊名 | FUTURE MEDICINAL CHEMISTRY
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| 出版日期 | 2016 |
| 卷号 | 8期号:1页码:17-27 |
| 关键词 | epimer NF-kappa B signaling pathway TDDFT ECD tetrahydroisoquinolinequinone |
| ISSN号 | 1756-8919 |
| DOI | 10.4155/fmc.15.169 |
| 文献子类 | Article |
| 英文摘要 | Background: Nudibranchs are slug-like invertebrates, well known as rich sources of biologically active secondary metabolites with highly chemical diversity and complexity. The production of such interesting metabolites was possibly influenced by their diet relationship with sponges such as Xestospongia. Results: Our continuous investigation of South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp. led to the isolation of two new and eight known metabolites (1-10). The absolute configurations were determined by time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) method and by the comparison of ECD spectra. In bioassays, 1-4 and 7 showed strong NF-kappa B inhibitory activity, 4-6 exhibited considerable cytotoxicity against A549 and HL-60 tumor cell lines. Conclusion: Five unusual isoquinolinequinones (3, 7-10) were discovered from both two animals, further confirmed their predator-prey relationship. Preliminary bioassay results and structure-activity relationship studies suggested that several isolated compounds were potential to be drug leads. |
| WOS关键词 | KAPPA-B ; SIGNALING PATHWAY ; MECHANISMS ; ASSAY |
| 资助项目 | National Marine '863' Projects[2013AA092902] ; National Marine '863' Projects[2012AA092105] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[41306130] ; Natural Science Foundation of China[41476063] ; NSFC Shandong Joint Fund for Marine Science Research Centers[U1406402] ; SCTSM Project[14431901100] ; SCTSM Project[15431901000] ; SKLDR/SIMM Projects[SIMM1501ZZ-03] ; SKLDR/SIMM Projects[CASIMM0120152039] ; Hungarian National Research Foundation[OTKA K105871] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000367193900004 |
| 出版者 | FUTURE SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276274]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Li, Xu-Wen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Univ Debrecen, Dept Organ Chem, H-4010 Debrecen, Hungary |
| 推荐引用方式 GB/T 7714 | Huang, Ren-Yong,Chen, Wen-Ting,Kurtan, Tibor,et al. Bioactive isoquinolinequinone alkaloids from the South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp.[J]. FUTURE MEDICINAL CHEMISTRY,2016,8(1):17-27. |
| APA | Huang, Ren-Yong.,Chen, Wen-Ting.,Kurtan, Tibor.,Mandi, Attila.,Ding, Jian.,...&Guo, Yue-Wei.(2016).Bioactive isoquinolinequinone alkaloids from the South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp..FUTURE MEDICINAL CHEMISTRY,8(1),17-27. |
| MLA | Huang, Ren-Yong,et al."Bioactive isoquinolinequinone alkaloids from the South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp.".FUTURE MEDICINAL CHEMISTRY 8.1(2016):17-27. |
入库方式： OAI收割
来源：上海药物研究所
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