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Effects of ion interactions with a cholesterol-rich bilayer

文献类型：期刊论文

作者Mao, Lingxue1; Yang, Linlin2; Zhang, Qiansen2; Jiang, Hualiang1,2; Yang, Huaiyu2
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2015-12-04
卷号468期号:1-2页码:125-129
关键词Ion mixture Cholesterol-rich bilayer Molecular dynamics Binding affinity
ISSN号0006-291X
DOI10.1016/j.bbrc.2015.10.149
文献子类Article
英文摘要Previous molecular dynamics (MD) simulations of ion-lipid interactions have focused on pure phospholipid bilayers. Many functional microdomains in membranes have a complex composition of cholesterol and phospholipids. Here, we reveal the distinctiveness of the interactions and the effects of the ions on a cholesterol-rich bilayer by performing MD simulations of a cholesterol-rich bilayer with a Na+/K+ mixture or a Na+/K+/Ca2+/Mg2+ mixture. The simulations reveal that Ca2+ maintains its dominant role in the interaction with the cholesterol-rich bilayer, but the binding affinity of Mg2+ to the cholesterol-rich bilayer is even weaker than the affinities of Ha(+) and K+, whereas its interaction with pure phospholipid bilayers is strong and is only slightly weaker than that of Ca2+. Additionally, it was found that the presence of additional divalent cations induces the headgroups of phospholipids to be more perpendicular to the membrane surface, reducing the lateral movement of lipids and slightly altering the ordering and packing of the cholesterol-rich bilayer, different from divalent cations, which strongly influence that ordering and packing of pure phospholipid bilayers. Therefore, this study indicates that cholesterol in the membrane could affect the interactions between membrane and cations. The findings could be helpful in understanding the biological processes relevant to regulation of cations in cholesterol-rich regions. (C) 2015 Elsevier Inc. All rights reserved.
WOS关键词MOLECULAR-DYNAMICS SIMULATION ; PHOSPHOLIPID-BILAYERS ; BIOLOGICAL IMPLICATION ; NA+ COUNTERIONS ; LIPID-MEMBRANES ; BINDING ; PHOSPHATIDYLCHOLINE ; PHOSPHATIDYLSERINE ; CA2+ ; CALCIUM
资助项目National Natural Science Foundation of China[21422208] ; National Natural Science Foundation of China[81173027] ; National Natural Science Foundation of China[81230076] ; National Natural Science Foundation of China[21210003] ; SA-SIBS Scholarship Program[00000000]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:000366240800020
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/276287]  
专题药物发现与设计中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Yang, Huaiyu
作者单位1.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Mao, Lingxue,Yang, Linlin,Zhang, Qiansen,et al. Effects of ion interactions with a cholesterol-rich bilayer[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,468(1-2):125-129.
APA Mao, Lingxue,Yang, Linlin,Zhang, Qiansen,Jiang, Hualiang,&Yang, Huaiyu.(2015).Effects of ion interactions with a cholesterol-rich bilayer.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,468(1-2),125-129.
MLA Mao, Lingxue,et al."Effects of ion interactions with a cholesterol-rich bilayer".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 468.1-2(2015):125-129.

入库方式： OAI收割

来源：上海药物研究所

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