New laurane-type sesquiterpenoids from the Chinese red alga Laurencia okamurai Yamada
文献类型：期刊论文
| 作者 | Li, Xiao-Lu; He, Wen-Fei; Li, Jia ; Lan, Le-Fu; Li, Xu-Wen; Guo, Yue-Wei
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| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 出版日期 | 2015-12-02 |
| 卷号 | 17期号:12页码:1146-1152 |
| ISSN号 | 1028-6020 |
| 关键词 | Chinese red algae Laurencia okamurai laurane sesquiterpene PTP1B inhibitor |
| DOI | 10.1080/10286020.2015.1102135 |
| 文献子类 | Article |
| 英文摘要 | Two new laurane-type sesquiterpenoids, debromo-3-hydroperoxy-3-epiaplysin (1) and debromo-3-hydroperoxyaplysin (2), together with seven known related compounds (3-9), were isolated from the Chinese red alga Laurencia okamurai. Their structures were elucidated by detailed analysis of spectroscopic data and by comparison with the literature. In bioassay, compounds 2, 4, 8, and 9 exhibited significant PTP1B inhibitory activity with IC50 values ranging from 4.9 to 14.9g/ml. |
| WOS关键词 | ORGANIC-MOLECULES ; NATURAL-PRODUCTS ; DERIVATIVES ; OBTUSA ; INHIBITORS |
| 资助项目 | National Marine "863" Projects[2013AA092902] ; National Marine "863" Projects[2012AA092105] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[41306130] ; Natural Science Foundation of China[41476063] ; NSFC Shangdong Joint Fund for Marine Science Research Centers[U1406402] ; SCTSM Project[14431901100] ; SCTSM Project[15431901000] ; SKLDR/SIMM Project[SIMM 1501ZZ-03] |
| WOS研究方向 | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS LTD |
| WOS记录号 | WOS:000368454000005 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276290]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Li, Xu-Wen |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiao-Lu,He, Wen-Fei,Li, Jia,et al. New laurane-type sesquiterpenoids from the Chinese red alga Laurencia okamurai Yamada[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2015,17(12):1146-1152. |
| APA | Li, Xiao-Lu,He, Wen-Fei,Li, Jia,Lan, Le-Fu,Li, Xu-Wen,&Guo, Yue-Wei.(2015).New laurane-type sesquiterpenoids from the Chinese red alga Laurencia okamurai Yamada.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,17(12),1146-1152. |
| MLA | Li, Xiao-Lu,et al."New laurane-type sesquiterpenoids from the Chinese red alga Laurencia okamurai Yamada".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 17.12(2015):1146-1152. |
入库方式： OAI收割
来源：上海药物研究所
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