Toll-like receptors: potential targets for lupus treatment
文献类型：期刊论文
| 作者 | Wu, Yan-wei; Tang, Wei ; Zuo, Jian-ping
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2015-12 |
| 卷号 | 36期号:12页码:1395-1407 |
| 关键词 | systemic lupus erythematosus autoimmune diseases Toll-like receptors TLR antagonists immune modulatory oligonucleotides small molecular inhibitors antibodies miRNAs |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2015.91 |
| 文献子类 | Review |
| 英文摘要 | Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the loss of tolerance to self-nuclear antigens. Accumulating evidence shows that Toll-like receptors (TLRs), previously proven to be critical for host defense, are implicated in the pathogenesis of autoimmune diseases by recognition of self-molecules. Genome-wide association studies, experimental mouse models and clinical sample studies have provided evidence for the involvement of TLRs, including TLR2/4, TLR5, TLR3 and TLR7/8/9, in SLE pathogenesis. A number of downstream proteins in the TLR signaling cascade (such as MyD88, IRAKs and IFN-alpha) are identified as potential therapeutic targets for SLE treatment. Numerous antagonists targeting TLR signaling, including oligonucleotides, small molecular inhibitors and antibodies, are currently under preclinical studies or clinical trials for SLE treatment. Moreover, the emerging new manipulation of TLR signaling by microRNA (miRNA) regulation shows promise for the future treatment of SLE. |
| WOS关键词 | ALPHA MONOCLONAL-ANTIBODY ; PATTERN-RECOGNITION RECEPTORS ; ANTIGEN-PRESENTING CELLS ; BLOOD MONONUCLEAR-CELLS ; AUTOREACTIVE B-CELLS ; I INTERFERON ; DENDRITIC CELLS ; AUTOANTIBODY PRODUCTION ; RHEUMATOID-ARTHRITIS ; PHASE-I |
| 资助项目 | National Natural Science Foundation of China[81273524] ; National Natural Science Foundation of China[81273525] ; National Natural Science Foundation of China[81322049] ; National Key Basic Research Program (973 Program)[2014CB541906] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5586887 |
| WOS记录号 | WOS:000366098300001 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276305]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Tang, Wei |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Lab Immunopharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yan-wei,Tang, Wei,Zuo, Jian-ping. Toll-like receptors: potential targets for lupus treatment[J]. ACTA PHARMACOLOGICA SINICA,2015,36(12):1395-1407. |
| APA | Wu, Yan-wei,Tang, Wei,&Zuo, Jian-ping.(2015).Toll-like receptors: potential targets for lupus treatment.ACTA PHARMACOLOGICA SINICA,36(12),1395-1407. |
| MLA | Wu, Yan-wei,et al."Toll-like receptors: potential targets for lupus treatment".ACTA PHARMACOLOGICA SINICA 36.12(2015):1395-1407. |
入库方式： OAI收割
来源：上海药物研究所
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