Formation of aversive memories associated with conditioned drug withdrawal requires BDNF expression in the amygdala in acute morphine-dependent rats
文献类型：期刊论文
| 作者 | Ju, Yun-yue; Long, Jian-dong; Liu, Yao; Liu, Jing-gen
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2015-12 |
| 卷号 | 36期号:12页码:1437-1443 |
| 关键词 | conditioned place aversion morphine naloxone aversive memory amygdala BDNF TrkB-FC K252a |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2015.94 |
| 文献子类 | Article |
| 英文摘要 | Aim: Brain-derived neurotrophic factor (BDNF) plays an important role in learning and memory in multiple brain areas. In the present study, we investigated the roles of BDNF in aversive memories associated with conditioned drug withdrawal in acute morphine-dependent rats. Methods: Conditioned place aversion (CPA) was induced in male SD rats exposed to a single dose of morphine (10 mg/kg, sc) followed by naloxone (0.3 mg/kg, sc). In some rats, BDNF receptor antagonist K252a (8.5 ng per side) or BDNF scavenger TrkB-FC (0.65 mu g per side) was bilaterally microinjected into amygdala before naloxone injection. BDNF mRNA and protein expression levels in amygdala were detected after the behavior testing. Results: CPA behavior was induced in rats by the naloxone-precipitated morphine withdrawal, which was accompanied by significantly increased levels of BDNF mRNA and protein in the amygdala. Bilateral microinjection of TrkB-FC or K252a into the amygdala completely blocked CPA behavior in the rats. Conclusion: Formation of aversive memories associated with conditioned drug withdrawal in acute morphine-dependent rats requires BDNF expression in the amygdala. |
| WOS关键词 | MEDIAL PREFRONTAL CORTEX ; NEUROTROPHIC FACTOR TRANSCRIPTION ; VENTRAL TEGMENTAL AREA ; SYNAPTIC PLASTICITY ; DORSAL HIPPOCAMPUS ; PLACE AVERSION ; ACTIN REARRANGEMENTS ; COCAINE-SEEKING ; IN-VIVO ; ADDICTION |
| 资助项目 | Ministry of Science and Technology of China[2013CB835100] ; National Natural Science Foundation of China[81130087] ; National Natural Science Foundation of China[91232716] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5586891 |
| WOS记录号 | WOS:000366098300005 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276306]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Jing-gen |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ju, Yun-yue,Long, Jian-dong,Liu, Yao,et al. Formation of aversive memories associated with conditioned drug withdrawal requires BDNF expression in the amygdala in acute morphine-dependent rats[J]. ACTA PHARMACOLOGICA SINICA,2015,36(12):1437-1443. |
| APA | Ju, Yun-yue,Long, Jian-dong,Liu, Yao,&Liu, Jing-gen.(2015).Formation of aversive memories associated with conditioned drug withdrawal requires BDNF expression in the amygdala in acute morphine-dependent rats.ACTA PHARMACOLOGICA SINICA,36(12),1437-1443. |
| MLA | Ju, Yun-yue,et al."Formation of aversive memories associated with conditioned drug withdrawal requires BDNF expression in the amygdala in acute morphine-dependent rats".ACTA PHARMACOLOGICA SINICA 36.12(2015):1437-1443. |
入库方式： OAI收割
来源：上海药物研究所
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