Chlorabietols A-C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii
文献类型：期刊论文
| 作者 | Xiong, Juan3; Hong, Zhi-Lai3; Gao, Li-Xin2; Shen, Jie1; Liu, Shu-Ting3; Yang, Guo-Xun3; Li, Jia2 ; Zeng, Huaqiang1; Hu, Jin-Feng3
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2015-11-06 |
| 卷号 | 80期号:21页码:11080-11085 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.5b01658 |
| 文献子类 | Article |
| 英文摘要 | Three unprecedented phloroglucinol-diterpene adducts, chlorabietols A-C (1-3), were isolated from the roots of the rare Chloranthaceae plant Chloranthus oldhamii. They represent a new class of compounds, featuring an abietane-type diterpenoid coupled with different alkenyl phloroglucinol units by forming a 2,3-dihydrofuran ring. Their structures were elucidated by detailed spectroscopic analysis, molecular modeling studies, and electronic circular dichroism calculations. Compounds 1-3 showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 12.6, 5.3, and 4.9 mu M, respectively. |
| WOS关键词 | PHOSPHATASE 1B INHIBITORS ; CYSTOPHORA ; METABOLITES ; CONSTITUENTS ; CHEMISTRY ; ALKYL |
| 资助项目 | NSFC[21472021] ; NSFC[81273401] ; NSFC[81202420] ; National Basic Research Program of China (973 Program)[2013CB530700] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000364435000065 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276329]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Li, Jia |
| 作者单位 | 1.Inst Bioengn & Nanotechnol, The Nanos 138669, Singapore 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Xiong, Juan,Hong, Zhi-Lai,Gao, Li-Xin,et al. Chlorabietols A-C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii[J]. JOURNAL OF ORGANIC CHEMISTRY,2015,80(21):11080-11085. |
| APA | Xiong, Juan.,Hong, Zhi-Lai.,Gao, Li-Xin.,Shen, Jie.,Liu, Shu-Ting.,...&Hu, Jin-Feng.(2015).Chlorabietols A-C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii.JOURNAL OF ORGANIC CHEMISTRY,80(21),11080-11085. |
| MLA | Xiong, Juan,et al."Chlorabietols A-C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii".JOURNAL OF ORGANIC CHEMISTRY 80.21(2015):11080-11085. |
入库方式： OAI收割
来源：上海药物研究所
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