Plantadeprate A, a Tricyclic Monoterpene Zwitterionic Guanidium, and Related Derivatives from the Seeds of Plantago depressa
文献类型：期刊论文
| 作者 | Zheng, Xiu-Mian2,3,4; Meng, Fan-Wang1,5; Geng, Fang2,3; Qi, Meng2,3; Luo, Cheng1 ; Yang, Li2,3; Wang, Zheng-Tao2,3
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2015-11 |
| 卷号 | 78期号:11页码:2822-2826 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.5b00368 |
| 文献子类 | Article |
| 英文摘要 | Two new alkaloids, plantadeprate A (1) and 1'-(4"-hydroxybutyl)-plantagoguanidinic acid (2), along with three known compounds, were isolated from the seeds of Plantago depressa. Their structures were elucidated by physical data analyses including NMR, MS, and electronic circular dichroism (ECD) methods. Plantadeprate A (1), a monoterpene zwitterionic guanidium, possesses a unique 5/5/6-tricyclic ring system. Its absolute configuration was determined by X-ray crystallography and computational methods. Compound 1, plumbagine D (3), and plantagoguanidinic acid (4) exhibited potential antihyperglycemic properties attributed to suppression of hepatic gluconeogenesis with inhibitory rates of 8.2%, 18.5%, and 12.5% at 40 mu M, respectively. |
| WOS关键词 | ANGIOTENSIN-CONVERTING ENZYME ; PHENYLETHANOID GLYCOSIDES ; BIOLOGICAL-ACTIVITIES ; INHIBITORY-ACTIVITY ; ALKALOIDS ; ENERGIES ; GLUCOSE ; MODEL ; L. |
| 资助项目 | National S&T Major Special Projects of China[2012ZX09103201-045] ; "Shu-Guang Scholar" Project of Shanghai Municipal Education Commission[11SG41] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000366005800041 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276338]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Li |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Key Lab Standardizat Chinese Med, Minist Educ, Shanghai 201203, Peoples R China; 3.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, SATCM Key Lab New Resources & Qual Evaluat Chines, Shanghai 201203, Peoples R China; 4.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China; 5.Shanghai Univ, Coll Sci, Dept Chem, Shanghai 200444, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Xiu-Mian,Meng, Fan-Wang,Geng, Fang,et al. Plantadeprate A, a Tricyclic Monoterpene Zwitterionic Guanidium, and Related Derivatives from the Seeds of Plantago depressa[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(11):2822-2826. |
| APA | Zheng, Xiu-Mian.,Meng, Fan-Wang.,Geng, Fang.,Qi, Meng.,Luo, Cheng.,...&Wang, Zheng-Tao.(2015).Plantadeprate A, a Tricyclic Monoterpene Zwitterionic Guanidium, and Related Derivatives from the Seeds of Plantago depressa.JOURNAL OF NATURAL PRODUCTS,78(11),2822-2826. |
| MLA | Zheng, Xiu-Mian,et al."Plantadeprate A, a Tricyclic Monoterpene Zwitterionic Guanidium, and Related Derivatives from the Seeds of Plantago depressa".JOURNAL OF NATURAL PRODUCTS 78.11(2015):2822-2826. |
入库方式： OAI收割
来源：上海药物研究所
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