Synthesis of Novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene Derivatives and Their Biological Evaluation Against Protein Tyrosine Phosphatase 1B
文献类型：期刊论文
| 作者 | Wang, Wen-Long1,2; Chen, Xia1; Gao, Li-Xin2; Sheng, Li2; Li, Jing-Ya2 ; Li, Jia2; Feng, Bainian1
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| 刊名 | CHEMICAL BIOLOGY & DRUG DESIGN
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| 出版日期 | 2015-11 |
| 卷号 | 86期号:5页码:1161-1167 |
| 关键词 | 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene derivatives inhibitors one-pot synthesis protein tyrosine phosphatase 1B structure-activity relationships |
| ISSN号 | 1747-0277 |
| DOI | 10.1111/cbdd.12587 |
| 文献子类 | Article |
| 英文摘要 | A series of novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene derivatives were designed, synthesized, and evaluated as a new class of inhibitors against protein tyrosine phosphatase 1B. Among them, compound 6f displayed moderate inhibitory activity with IC50 of 2.87 +/- 0.24 mu M and can be used as a novel lead compound for the design of inhibitors of protein tyrosine phosphatase 1B. |
| WOS关键词 | PTP1B ; INHIBITORS ; BINDING ; POTENT |
| 资助项目 | National Natural Science Foundation of China[81125023] ; National Natural Science Foundation of China[21472069] ; State Key Laboratory of Drug Research[SIMM1302KF-05] ; Fundamental Research Funds for Central Universities[JUSRP1040] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000365404100020 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276342]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Feng, Bainian |
| 作者单位 | 1.Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Wen-Long,Chen, Xia,Gao, Li-Xin,et al. Synthesis of Novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene Derivatives and Their Biological Evaluation Against Protein Tyrosine Phosphatase 1B[J]. CHEMICAL BIOLOGY & DRUG DESIGN,2015,86(5):1161-1167. |
| APA | Wang, Wen-Long.,Chen, Xia.,Gao, Li-Xin.,Sheng, Li.,Li, Jing-Ya.,...&Feng, Bainian.(2015).Synthesis of Novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene Derivatives and Their Biological Evaluation Against Protein Tyrosine Phosphatase 1B.CHEMICAL BIOLOGY & DRUG DESIGN,86(5),1161-1167. |
| MLA | Wang, Wen-Long,et al."Synthesis of Novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene Derivatives and Their Biological Evaluation Against Protein Tyrosine Phosphatase 1B".CHEMICAL BIOLOGY & DRUG DESIGN 86.5(2015):1161-1167. |
入库方式： OAI收割
来源：上海药物研究所
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