NIR absorbing DICPO derivatives applied to wide range of pH and detection of glutathione in tumor
文献类型：期刊论文
| 作者 | Bao, Bin1; Liu, Meng2; Liu, Yaqian1; Zhang, Xuan1 ; Zang, Yi2; Li, Jia2; Lu, Wei1
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2015-10-14 |
| 卷号 | 71期号:41页码:7865-7868 |
| 关键词 | NIR DICPO GSH pH |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2015.08.020 |
| 文献子类 | Article |
| 英文摘要 | New DPCO derivatives were developed for application at a wide range of pH values. CI-DPCO exhibited better optical properties than DPCO in solutions with pH values from 5.0 to 9.0 and was preferable for the design of probes, especially for the imaging of a tumor micro-environment which is acidic. With CI-DPCO probe 1 was designed for the detection of GSH. Probe I was sensitive to GSH in environments at pH values of 5.7 and 7.4, and strong near-infrared fluorescence was detected. Moreover, probe 1 had good response to the endogenous GSH in living cells, which suggested that CI-DPCO has potential in the design of other tumor-associated probes. (c) 2015 Elsevier Ltd. All rights |
| WOS关键词 | LIVING CELLS ; FLUORESCENT-PROBES ; RED ; CHEMOTHERAPY ; BIOTHIOLS ; CYSTEINE |
| 资助项目 | National Natural Science Foundation of China[81172936] ; National Natural Science Foundation of China[91213303] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000362534000007 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276363]  |
| 专题 | 国家新药筛选中心 中国科学院上海药物研究所 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Li, Jia |
| 作者单位 | 1.E China Normal Univ, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bao, Bin,Liu, Meng,Liu, Yaqian,et al. NIR absorbing DICPO derivatives applied to wide range of pH and detection of glutathione in tumor[J]. TETRAHEDRON,2015,71(41):7865-7868. |
| APA | Bao, Bin.,Liu, Meng.,Liu, Yaqian.,Zhang, Xuan.,Zang, Yi.,...&Lu, Wei.(2015).NIR absorbing DICPO derivatives applied to wide range of pH and detection of glutathione in tumor.TETRAHEDRON,71(41),7865-7868. |
| MLA | Bao, Bin,et al."NIR absorbing DICPO derivatives applied to wide range of pH and detection of glutathione in tumor".TETRAHEDRON 71.41(2015):7865-7868. |
入库方式： OAI收割
来源：上海药物研究所
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