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Total Synthesis of Two Diastereomers of Megastigmane Glycoside Lauroside B

文献类型：期刊论文

作者Fu, Xiaozhe1; Zhang, Mingming2; Gao, Qi4; Yang, Fengling1; Li, Yingxia2; Ding, Ning2,3
刊名JOURNAL OF CARBOHYDRATE CHEMISTRY
出版日期2015-10-13
卷号34期号:8页码:445-459
关键词Lauroside B Megastigmane Melanoma NF-B Diastereomers
ISSN号0732-8303
DOI10.1080/07328303.2015.1095925
文献子类Article
英文摘要Lauroside B, a megastigmane sesquiterpene glycoside isolated from L. nobilis leaves, has the potential effect of inducing apoptosis of several highly aggressive malignant melanoma cell lines. To promote the potential development of lauroside B as a possible chemotherapeutic agent to treat human melanoma, the structure and activity relationship studies should be of great importance. In this work, two diastereomers of lauroside B were synthesized through a straightforward approach and the details of the key steps were investigated, which would provide useful information for developing an efficient method toward the synthesis of lauroside B and its structural analogs.
WOS关键词SESQUITERPENE LACTONES ; NATURAL-PRODUCTS ; DRUG DISCOVERY ; APOPTOSIS ; MELANOMA ; THERAPY ; CELLS ; CYTOTOXICITY ; KETONES ; PEOPLE
资助项目State Key Laboratory of Drug Research[SIMM1403KF-08] ; "Zhuo Xue" Talent Plan of Fudan University[00000000]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000366302500001
出版者TAYLOR & FRANCIS INC
源URL[http://119.78.100.183/handle/2S10ELR8/276364]  
专题新药研究国家重点实验室
中科院受体结构与功能重点实验室
通讯作者Ding, Ning
作者单位1.Zhengzhou Univ, Dept Chem & Mol Engn, Zhengzhou 450001, Peoples R China;
2.Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201203, Peoples R China;
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
4.Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30605 USA
推荐引用方式
GB/T 7714		 Fu, Xiaozhe,Zhang, Mingming,Gao, Qi,et al. Total Synthesis of Two Diastereomers of Megastigmane Glycoside Lauroside B[J]. JOURNAL OF CARBOHYDRATE CHEMISTRY,2015,34(8):445-459.
APA Fu, Xiaozhe,Zhang, Mingming,Gao, Qi,Yang, Fengling,Li, Yingxia,&Ding, Ning.(2015).Total Synthesis of Two Diastereomers of Megastigmane Glycoside Lauroside B.JOURNAL OF CARBOHYDRATE CHEMISTRY,34(8),445-459.
MLA Fu, Xiaozhe,et al."Total Synthesis of Two Diastereomers of Megastigmane Glycoside Lauroside B".JOURNAL OF CARBOHYDRATE CHEMISTRY 34.8(2015):445-459.

入库方式： OAI收割

来源：上海药物研究所

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