Blood Pyrrole-Protein Adducts-A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans
文献类型：期刊论文
| 作者 | Ruan, Jianqing1; Gao, Hong2; Li, Na1; Xue, Junyi1,3,4; Chen, Jie2; Ke, Changqiang3,4,5,6 ; Ye, Yang3,4,5,6; Fu, Peter Pi-Cheng7; Zheng, Jiang8,9; Wang, Jiyao2
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| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS
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| 出版日期 | 2015-10-02 |
| 卷号 | 33期号:4页码:404-421 |
| ISSN号 | 1059-0501 |
| 关键词 | hepatic sinusoidal obstruction syndrome hepatotoxicity pyrrolizidine alkaloids pyrrole-protein adducts |
| DOI | 10.1080/10590501.2015.1096882 |
| 文献子类 | Article |
| 英文摘要 | Pyrrolizidine alkaloids (PAs) induce liver injury (PA-ILI) and is very likely to contribute significantly to drug-induced liver injury (DILI). In this study we used a newly developed ultra-high performance liquid chromatography-triple quadrupole-mass spectrometry (UHPLC-MS)-based method to detect and quantitate blood pyrrole-protein adducts in DILI patients. Among the 46 suspected DILI patients, 15 were identified as PA-ILI by the identification of PA-containing herbs exposed. Blood pyrrole-protein adducts were detected in all PA-ILI patients (100%). These results confirm that PA-ILI is one of the major causes of DILI and that blood pyrrole-protein adducts quantitated by the newly developed UHPLC-MS method can serve as a specific biomarker of PA-ILI. |
| WOS关键词 | SINUSOIDAL-OBSTRUCTION SYNDROME ; HEPATIC VENOOCCLUSIVE DISEASE ; METABOLIC-ACTIVATION ; HEPATOTOXICITY ; TOXICITY ; EXPOSURE ; GENOTOXICITY ; FAILURE ; ARTICLE |
| 资助项目 | Research Grant Council of Hong Kong SAR[469712] ; Research Grant Council of Hong Kong SAR[471013] ; Research Grant Council of Hong Kong SAR[2140898] ; CUHK[4054134] ; CUHK[4054215] ; CUHK School of Biomedical Sciences - Seed Fund for Joint Establishments, Shanghai Committee of Science and Technology, P.R. China[12401907400] ; Ministry of Education in China[KEF152006] ; National Natural Science Foundation of China[81430086] ; National Natural Science Foundation of China[81373471] |
| WOS研究方向 | Oncology ; Environmental Sciences & Ecology ; Toxicology |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS INC |
| WOS记录号 | WOS:000365684500002 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276372]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Lin, Ge |
| 作者单位 | 1.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China; 2.Fudan Univ, Div Gastroenterol, Zhongshan Hosp, Shanghai 200433, Peoples R China; 3.Chinese Acad Sci, Joint Res Lab Promoting Globalizat Tradit Chinese, Hong Kong, Hong Kong, Peoples R China; 4.Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Beijing 100864, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Beijing 100864, Peoples R China; 7.Natl Ctr Toxicol Res, Jefferson, AR 72079 USA; 8.Univ Washington, Dept Pediat, Seattle Childrens Res Inst, Ctr Dev Therapeut,Div Gastroenterol, Washington, DC USA; 9.Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ruan, Jianqing,Gao, Hong,Li, Na,et al. Blood Pyrrole-Protein Adducts-A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans[J]. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS,2015,33(4):404-421. |
| APA | Ruan, Jianqing.,Gao, Hong.,Li, Na.,Xue, Junyi.,Chen, Jie.,...&Lin, Ge.(2015).Blood Pyrrole-Protein Adducts-A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans.JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS,33(4),404-421. |
| MLA | Ruan, Jianqing,et al."Blood Pyrrole-Protein Adducts-A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans".JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS 33.4(2015):404-421. |
入库方式： OAI收割
来源：上海药物研究所
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