Anti-inflammatory Inositol Derivatives from the Whole Plant of Inula cappa
文献类型：期刊论文
| 作者 | Wu, Jiewei1,2,5; Tang, Chunping1,2,5 ; Yao, Sheng1,2,5; Zhang, Lei3,4; Ke, Changqiang1,2,5; Feng, Linyin3,4; Lin, Ge5,7; Ye, Yang1,2,5,6
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2015-10 |
| 卷号 | 78期号:10页码:2332-2338 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.5b00135 |
| 文献子类 | Article |
| 英文摘要 | Twelve new inositol derivatives, classified into myoinositol (1-6) and 1-inositol (10-15) types, along with five known analogues were isolated from the whole plant of Inula cappa. The structures of the new compounds were established by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. All the tested compounds showed antiinflammatory activities against the production of NO in RAW264.7 macrophages stimulated by lipopolysaccharide, with IC50 values ranging from 7 to 23 mu M. |
| WOS关键词 | SESQUITERPENE LACTONES ; PHENOLIC GLYCOSIDES ; IP6 ; FLAVONOIDS ; METABOLISM ; EVOLUTION ; AGENT |
| 资助项目 | National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2015ZX09103002] ; National Natural Science Funds of China[81302657] ; National Natural Science Funds of China[81573305] ; National Natural Science Funds of China[81473112] ; Ministry of Science and Technology[2010DFA30980] ; Chinese Academy of Sciences[KSZD-EW-Z-004-01] ; Shanghai Commission of Science and Technology[11DZ1970700] ; Shanghai Commission of Science and Technology[12JC1410300] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000363995800004 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276379]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ye, Yang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Neuropharmacol, Shanghai 201203, Peoples R China; 5.Joint Res Lab Promoting Globalizat Tradit Chinese, Hong Kong, Hong Kong, Peoples R China; 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China 7.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wu, Jiewei,Tang, Chunping,Yao, Sheng,et al. Anti-inflammatory Inositol Derivatives from the Whole Plant of Inula cappa[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(10):2332-2338. |
| APA | Wu, Jiewei.,Tang, Chunping.,Yao, Sheng.,Zhang, Lei.,Ke, Changqiang.,...&Ye, Yang.(2015).Anti-inflammatory Inositol Derivatives from the Whole Plant of Inula cappa.JOURNAL OF NATURAL PRODUCTS,78(10),2332-2338. |
| MLA | Wu, Jiewei,et al."Anti-inflammatory Inositol Derivatives from the Whole Plant of Inula cappa".JOURNAL OF NATURAL PRODUCTS 78.10(2015):2332-2338. |
入库方式： OAI收割
来源：上海药物研究所
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