Natural beta-Dihydroagarofuran-Type Sesquiterpenoids as Cognition-Enhancing and Neuroprotective Agents from Medicinal Plants of the Genus Celastrus
文献类型：期刊论文
| 作者 | Ning, Ruonan1; Lei, Yun2; Liu, Shuangzhu1; Wang, Huan2; Zhang, Rujun1; Wang, Wei2; Zhu, Yingdong1; Zhang, Haiyan2 ; Zhao, Weimin1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2015-09 |
| 卷号 | 78期号:9页码:2175-2186 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.5b00234 |
| 文献子类 | Article |
| 英文摘要 | Alzheimer's disease (AD) is an irreversible, multifaceted, and progressive neurodegenerative disorder. Over the past 30 years, the search for anti-AD drugs has been primarily based on the cholinergic deficiency hypothesis and/or the beta-amyloid (A beta) cascade hypothesis. In this study, we report the identification of 16 new and 38 known beta-dihydroagarofuran-type sesquiterpenoids from Celastrus flagellaris and Celastrus angulatus. The beta-dihydroagarofuran-type sesquiterpenoids 58, 59, 61, and 63 significantly attenuated scopolamine-induced prolonged escape latency and increased number of errors compared with the control group. At 10 mu M, 21 of the 62 tested beta-dihydroagarofuran-type sesquiterpenoids rescued A beta(25-35)-induced SH-SY5Y cells from viability reduction, which increased the cell viability from 64.6% for the model to more than 74.0%. The majority of the beta-dihydroagarofuran-type sesquiterpenoids with ester groups exhibited stronger activity than those with free hydroxy groups or without substituents at the same positions. These results identified a new chemical skeleton as drug lead for the investigation of novel therapeutic agents against AD. |
| WOS关键词 | DEPENDENT MULTIDRUG-RESISTANCE ; LEISHMANIA-TROPICA LINE ; ALZHEIMERS-DISEASE ; POLYOL ESTERS ; TRIPTERYGIUM-WILFORDII ; PYRIDINE ALKALOIDS ; DRUG DEVELOPMENT ; CLINICAL-TRIALS ; SH-SY5Y CELLS ; ANGULATUS |
| 资助项目 | National Natural Science Foundation of China[81473113] ; State Key Laboratory of Drug Research[SIMM1403KF-04] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000362056200005 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276406]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 天然药物化学研究室 |
| 通讯作者 | Zhang, Haiyan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ning, Ruonan,Lei, Yun,Liu, Shuangzhu,et al. Natural beta-Dihydroagarofuran-Type Sesquiterpenoids as Cognition-Enhancing and Neuroprotective Agents from Medicinal Plants of the Genus Celastrus[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(9):2175-2186. |
| APA | Ning, Ruonan.,Lei, Yun.,Liu, Shuangzhu.,Wang, Huan.,Zhang, Rujun.,...&Zhao, Weimin.(2015).Natural beta-Dihydroagarofuran-Type Sesquiterpenoids as Cognition-Enhancing and Neuroprotective Agents from Medicinal Plants of the Genus Celastrus.JOURNAL OF NATURAL PRODUCTS,78(9),2175-2186. |
| MLA | Ning, Ruonan,et al."Natural beta-Dihydroagarofuran-Type Sesquiterpenoids as Cognition-Enhancing and Neuroprotective Agents from Medicinal Plants of the Genus Celastrus".JOURNAL OF NATURAL PRODUCTS 78.9(2015):2175-2186. |
入库方式： OAI收割
来源：上海药物研究所
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