Inhibition of Breast Cancer Metastasis by Pluronic Copolymers with Moderate Hydrophilic-Lipophilic Balance
文献类型：期刊论文
| 作者 | Sun, Huiping1,2,3; Meng, Qingshuo1,3; Tang, Shan1,3; Su, Jinghan1,3; Yin, Qi1,3 ; Chen, Lingli1,3; Gu, Wangwen1,3; Yu, Haijun1,3; Zhang, Zhiwen1,3; Wang, Siling2
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| 刊名 | MOLECULAR PHARMACEUTICS
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| 出版日期 | 2015-09 |
| 卷号 | 12期号:9页码:3323-3331 |
| 关键词 | metastasis Pluronic copolymers doxorubicin P85 breast cancer |
| ISSN号 | 1543-8384 |
| DOI | 10.1021/acs.molpharmaceut.5b00319 |
| 文献子类 | Article |
| 英文摘要 | Metastasis is the primary cause resulting in the high mortality of breast cancer. The inherent antimetastasis bioactivity of Pluronic copolymers with a wide range of hydrophilic-lipophilic balance (HLB) including Pluronic L61, P85, P123, F127, F68, and F108 was first explored on metastatic 4T1 breast cancer cells. The results indicated that P85 and P123 could strongly inhibit the migration and invasion of 4T1 cells. The effects of the polymers on cell healing, migration, and invasion exhibited bell-shaped dependencies on HLB of Pluronic copolymers, and the better antimetastasis effects of Pluronic copolymers could be achieved with the HLB between 8 and 16. P85 and P123 themselves could significantly inhibit pulmonary metastasis in 4T1 mammary tumor metastasis model in situ. In addition, a synergetic antimetastasis effect could be achieved during drug combination of doxorubicin hydrochloride (DOX) and P85 or P123 intravenously. The metastasis effects of P85 and P123 both in vitro and in vivo were partially attributed to the downregulation of matrix metalloproteinase-9 (MMP-9). Therefore, Pluronic copolymers with moderate HLB 8-16 such as P85 and P123 could be promising excipients with therapeutics in drug delivery systems to inhibit breast cancer metastasis. |
| WOS关键词 | P85-PEI/TPGS COMPLEX NANOPARTICLES ; BLOCK-COPOLYMERS ; AMPHIPHILIC COPOLYMERS ; POLYMERIC MICELLES ; TUMOR-METASTASIS ; CACO-2 CELLS ; CO-DELIVERY ; PACLITAXEL ; TWIST ; DISSEMINATION |
| 资助项目 | National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81373359] ; National Basic Research Program of China[2013CB932704] |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000361086800022 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276413]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Wang, Siling |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Huiping,Meng, Qingshuo,Tang, Shan,et al. Inhibition of Breast Cancer Metastasis by Pluronic Copolymers with Moderate Hydrophilic-Lipophilic Balance[J]. MOLECULAR PHARMACEUTICS,2015,12(9):3323-3331. |
| APA | Sun, Huiping.,Meng, Qingshuo.,Tang, Shan.,Su, Jinghan.,Yin, Qi.,...&Li, Yaping.(2015).Inhibition of Breast Cancer Metastasis by Pluronic Copolymers with Moderate Hydrophilic-Lipophilic Balance.MOLECULAR PHARMACEUTICS,12(9),3323-3331. |
| MLA | Sun, Huiping,et al."Inhibition of Breast Cancer Metastasis by Pluronic Copolymers with Moderate Hydrophilic-Lipophilic Balance".MOLECULAR PHARMACEUTICS 12.9(2015):3323-3331. |
入库方式： OAI收割
来源：上海药物研究所
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