Alkylations of Arylboronic Acids including Difluoroethylation/Trifluoroethylation via Nickel-Catalyzed Suzuki Cross-Coupling Reaction
文献类型：期刊论文
| 作者 | Zhang, Xiaofei; Yang, Chunhao
|
| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
 |
| 出版日期 | 2015-08-24 |
| 卷号 | 357期号:12页码:2721-2727 |
| 关键词 | C(sp(3))-C(sp(2)) bond formation 2,2-difluoroethylation nickel catalyst Suzuki cross-coupling 2,2,2-trifluoroethylation |
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.201500346 |
| 文献子类 | Article |
| 英文摘要 | An efficient alkylation method of functionalized alkyl halides under mild nickel-catalyzed C(sp(3))-C(sp(2)) Suzuki cross-coupling conditions is described. The features of this approach are excellent functional group compatibility, low cost nickel catalyst, and the use of a mild base. This is also the first successful example of the nickel-catalyzed direct 2,2-difluoroethylation or 2,2,2-trifluoroethylation of aryl-/heteroarylboronic acids. |
| WOS关键词 | ARYL GRIGNARD-REAGENTS ; SECONDARY ALKYL BROMIDES ; CARBON BOND FORMATION ; BORONIC ACIDS ; BETA-HYDROGENS ; MEDICINAL CHEMISTRY ; HALIDES ; PALLADIUM ; COMPLEX ; LIGAND |
| 资助项目 | National Natural Science Foundation of China[81321092] ; SKLDR/SIMM[SIMM1403ZZ-01] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000360313400015 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276433]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Chunhao |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaofei,Yang, Chunhao. Alkylations of Arylboronic Acids including Difluoroethylation/Trifluoroethylation via Nickel-Catalyzed Suzuki Cross-Coupling Reaction[J]. ADVANCED SYNTHESIS & CATALYSIS,2015,357(12):2721-2727. |
| APA | Zhang, Xiaofei,&Yang, Chunhao.(2015).Alkylations of Arylboronic Acids including Difluoroethylation/Trifluoroethylation via Nickel-Catalyzed Suzuki Cross-Coupling Reaction.ADVANCED SYNTHESIS & CATALYSIS,357(12),2721-2727. |
| MLA | Zhang, Xiaofei,et al."Alkylations of Arylboronic Acids including Difluoroethylation/Trifluoroethylation via Nickel-Catalyzed Suzuki Cross-Coupling Reaction".ADVANCED SYNTHESIS & CATALYSIS 357.12(2015):2721-2727. |
入库方式： OAI收割
来源：上海药物研究所
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