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Brominated polyunsaturated lipids with protein tyrosine phosphatase-1B inhibitory activity from Chinese marine sponge Xestospongia testudinaria

文献类型：期刊论文

作者He, Wen-Fei1,2; Liang, Lin-Fu2; Cai, You-Sheng2; Gao, Li-Xin2; Li, Yu-Fen2; Li, Jia2; Liu, Hai-Li2; Guo, Yue-Wei2
刊名JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
出版日期2015-08-03
卷号17期号:8页码:861-866
关键词brominated polyunsaturated lipid sponge Xestospongia testudinaria PTP1B inhibitory activity
ISSN号1028-6020
DOI10.1080/10286020.2015.1026334
文献子类Article
英文摘要A new brominated polyunsaturated lipid, methyl (E,E)-14,14-dibromo-4,6,13-tetradecatrienoate (1), along with three known related analogues (2-4), were isolated from the Et2O-soluble portion of the acetone extract of Chinese marine sponge Xestospongia testudinaria treated with diazomethane. The structure of the new compound was elucidated by detailed spectroscopic analysis and by comparison with literature data. Compound 3 exhibited significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a key target for the treatment of type II diabetes and obesity, with an IC50 value of 5.30 +/- 0.61M, when compared to the positive control oleanolic acid (IC50=2.39 +/- 0.26M).
WOS关键词ACETYLENIC FATTY-ACIDS ; DISCOVERY ; PTP1B ; PETROFORMYNES
资助项目Natural Science Foundation of China[81273430] ; Natural Science Foundation of China[41306130] ; Natural Science Foundation of China[81302692] ; Natural Science Foundation of China[41476063] ; National Marine '863' Project[2012AA092105] ; National Marine '863' Project[2013AA092902] ; China Postdoctoral Science Foundation[2012M520956] ; China Postdoctoral Science Foundation[2014T70443] ; SKLDR/SIMM Project[1501ZZ-03] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1406402] ; SCTSM Project[14431901100]
WOS研究方向Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000359639700014
出版者TAYLOR & FRANCIS LTD
源URL[http://119.78.100.183/handle/2S10ELR8/276441]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Liu, Hai-Li
作者单位1.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China;
2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 He, Wen-Fei,Liang, Lin-Fu,Cai, You-Sheng,et al. Brominated polyunsaturated lipids with protein tyrosine phosphatase-1B inhibitory activity from Chinese marine sponge Xestospongia testudinaria[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2015,17(8):861-866.
APA He, Wen-Fei.,Liang, Lin-Fu.,Cai, You-Sheng.,Gao, Li-Xin.,Li, Yu-Fen.,...&Guo, Yue-Wei.(2015).Brominated polyunsaturated lipids with protein tyrosine phosphatase-1B inhibitory activity from Chinese marine sponge Xestospongia testudinaria.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,17(8),861-866.
MLA He, Wen-Fei,et al."Brominated polyunsaturated lipids with protein tyrosine phosphatase-1B inhibitory activity from Chinese marine sponge Xestospongia testudinaria".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 17.8(2015):861-866.

入库方式： OAI收割

来源：上海药物研究所

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