Prefrontal cortex gates acute morphine action on dopamine neurons in the ventral tegmental area
文献类型：期刊论文
| 作者 | Liu, Changliang1,2; Fang, Xing2; Wu, Qianqian1; Jin, Guozhang1 ; Zhen, Xuechu2
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| 刊名 | NEUROPHARMACOLOGY
 |
| 出版日期 | 2015-08 |
| 卷号 | 95页码:299-308 |
| ISSN号 | 0028-3908 |
| 关键词 | Morphine Dopamine Single-unit recording Ventral tegmental area Prefrontal cortex |
| DOI | 10.1016/j.neuropharm.2015.03.037 |
| 文献子类 | Article |
| 英文摘要 | Morphine excites dopamine (DA) neurons in the ventral tegmental area (VTA), an effect mediated by both local and systemic mechanisms. While the importance of the prefrontal cortex (PFC) - VTA circuit in opiate addiction is well established, little is known about how the PFC regulates the activity of VTA DA neurons upon morphine stimulation. One major challenge is that VTA DA neurons are highly heterogeneous in terms of projection and regulation, making their responses to PFC manipulations variable. Our previous work has identified a subgroup of VTA DA neurons exhibiting significant slow oscillation in their firing sequence, and demonstrated that most of these neurons are functionally connected with the PFC. In the present study, we focus our efforts only on VTA DA neurons expressing strong slow oscillation, and report that blocking the neuronal activity in the PFC remarkably attenuates the morphine-induced excitation of these neurons. Using in vivo microdialysis, we find that inactivation of the PFC also reduces the morphine-induced elevation of DA levels in the nucleus accumbens (NAc). Furthermore, 24 h after only single morphine exposure, PFC-inactivation failed to prevent subsequent morphine challenge from exciting VTA DA neurons, which is paralleled by altered response of PFC pyramidal neurons to morphine stimulation. Our results indicate that the PFC gates acute morphine action on a subset of VTA DA neurons, which is highly plastic and can be functionally remodeled by morphine exposure. (C) 2015 Elsevier Ltd. All rights reserved. |
| WOS关键词 | OPIATE REWARD ; CHOLINERGIC INTERNEURONS ; NUCLEUS-ACCUMBENS ; INDUCED ANALGESIA ; INDUCED RELAPSE ; FIRING PATTERN ; RAT ; WITHDRAWAL ; INHIBITION ; ADDICTION |
| 资助项目 | National Science Foundation of China[81130023] ; National Science Foundation of China[30825042] ; National Basic Research Plan (973) of the Ministry of Science and Technology of China[2009CB522000] ; National Basic Research Plan (973) of the Ministry of Science and Technology of China[2011CB5C4403] ; Priority Academic Program Development of Jiangsu Higher Education Institutes (PAPD)[00000000] ; Jiangsu Science and Technology Commission[BY2011131] |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000357349100029 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276460]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 院士及顾问专家 |
| 通讯作者 | Zhen, Xuechu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Medica, Dept Pharmacol,State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Soochow Univ, Dept Pharmacol, Coll Pharmaceut Sci, Jiangsu Key Lab Translat Res & Therapy Neuropsyco, Suzhou 215006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Changliang,Fang, Xing,Wu, Qianqian,et al. Prefrontal cortex gates acute morphine action on dopamine neurons in the ventral tegmental area[J]. NEUROPHARMACOLOGY,2015,95:299-308. |
| APA | Liu, Changliang,Fang, Xing,Wu, Qianqian,Jin, Guozhang,&Zhen, Xuechu.(2015).Prefrontal cortex gates acute morphine action on dopamine neurons in the ventral tegmental area.NEUROPHARMACOLOGY,95,299-308. |
| MLA | Liu, Changliang,et al."Prefrontal cortex gates acute morphine action on dopamine neurons in the ventral tegmental area".NEUROPHARMACOLOGY 95(2015):299-308. |
入库方式： OAI收割
来源：上海药物研究所
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