Tanshinone I inhibits tumor angiogenesis by reducing STAT3 phosphorylation at TYR705 and hypoxia-induced HIF-1a accumulation in both endothelial and tumor cells
文献类型：期刊论文
| 作者 | Wang, Yan1,2; Li, Jia-Xin1; Wang, Ying-Qing1 ; Miao, Ze-Hong1
|
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2015-06-30 |
| 卷号 | 6期号:18页码:16031-16042 |
| 关键词 | tanshinone I angiogenesis Stat3 HIF-1 alpha VEGF |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.3648 |
| 文献子类 | Article |
| 英文摘要 | Tanshinone I (Tanshinone-1), a major active principle of Salvia miltiorrhiza (Danshen), has been shown to overcome tumor drug resistance and metastasis. Here we report that tanshinone-1 inhibits angiogenesis. Tanshinone-1 inhibited proliferation, migration and tube formation of vascular endothelial cells, rat aortic ring sprouting and the neovascularization of the chick chorioallantoic membrane in a concentration-dependent manner. In endothelial cells, tanshinone-1 almost completely inhibited phosphorylation of Stat3 at Tyr705 regardless of hypoxia or normoxia but only slightly decreased the hypoxia-induced HIF-1a accumulation. In tumor cells, contrastively, tanshinone-1 could not only make phosphorylation of Stat3 at Tyr705 disappear but also reduce the hypoxia-induced accumulation of HIF-1a to its baseline levels at normoxia. Consequently, VEGF secretion from tumor cells was reduced, which could potentiate the direct inhibition of tanshinone-1 on endothelial cells. Together with its overcoming tumor drug resistance and metastasis, our results reveal unique characteristics of tanshinone-1 and its improved derivatives as promising angiogenesis inhibitors. |
| WOS关键词 | BREAST-CANCER CELLS ; GROWTH ; EXPRESSION ; TRIPTOLIDE ; DEGRADATION ; ACTIVATION ; MECHANISMS ; THERAPY |
| 资助项目 | Science and Technology Commission of Shanghai Municipality[13XD1404200] ; National Basic Research Program of China[2012CB932502] ; National Science & Technology Major Project of China[2012ZX09301-001-002] ; National Natural Science Foundation of China[81321092] ; Program for Science and Technology Innovation of the Chinese Academy of Sciences[00000000] ; State Key Laboratory of Drug Research[00000000] |
| WOS研究方向 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000359012000044 |
| 出版者 | IMPACT JOURNALS LLC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276488]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Miao, Ze-Hong |
| 作者单位 | 1.Chinese Acad Sci, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Nanchang Univ, Coll Pharm, Nanchang 330006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yan,Li, Jia-Xin,Wang, Ying-Qing,et al. Tanshinone I inhibits tumor angiogenesis by reducing STAT3 phosphorylation at TYR705 and hypoxia-induced HIF-1a accumulation in both endothelial and tumor cells[J]. ONCOTARGET,2015,6(18):16031-16042. |
| APA | Wang, Yan,Li, Jia-Xin,Wang, Ying-Qing,&Miao, Ze-Hong.(2015).Tanshinone I inhibits tumor angiogenesis by reducing STAT3 phosphorylation at TYR705 and hypoxia-induced HIF-1a accumulation in both endothelial and tumor cells.ONCOTARGET,6(18),16031-16042. |
| MLA | Wang, Yan,et al."Tanshinone I inhibits tumor angiogenesis by reducing STAT3 phosphorylation at TYR705 and hypoxia-induced HIF-1a accumulation in both endothelial and tumor cells".ONCOTARGET 6.18(2015):16031-16042. |
入库方式： OAI收割
来源：上海药物研究所
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