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Anti-HIV Securinega alkaloid oligomers from Flueggea virosa

文献类型：期刊论文

作者Zhang, Hua1; Han, Ying-Shan2; Wainberg, Mark A.2; Yue, Jian-Min1
刊名TETRAHEDRON
出版日期2015-06-03
卷号71期号:22页码:3671-3679
关键词Anti-HIV Securinega alkaloid Flueggea virosa Fluevirosinine Alkaloid oligomer
ISSN号0040-4020
DOI10.1016/j.tet.2014.10.064
文献子类Article
英文摘要An MS guided fractionation of the alkaloidal constituents of Flueggea virosa has yielded nine new Securinega alkaloid oligomers, fluevirosinines B-J (1-9). The absolute structures of these oligomers have been characterized on the basis of spectroscopic data and biogenetic consideration. Fluevirosinines B-E (1-4) are four tetramers with new connecting sequences or new oligomerizing patterns, and fluevirosinines G-J (6-9) represent the first examples of pentamers of the Securinega alkaloid family. Among these alkaloids, fluevirosinine B (1) showed the best anti-HIV activity with an EC50 value of 14.1 +/- 1.2 (C) 2014 Elsevier Ltd. All rights reserved.
WOS关键词DIMERIC INDOLIZIDINE ALKALOIDS
资助项目National Natural Science Foundation for Excellent Young Scientists of P. R. China[81322045] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[00000000]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000355051000016
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/276498]  
专题天然药物化学研究室
中科院受体结构与功能重点实验室
期刊编辑部
新药研究国家重点实验室
分析化学研究室
通讯作者Yue, Jian-Min
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;
2.McGill Univ, Aids Ctr, Lady Davis Inst Med Res, Jewish Gen Hosp, Montreal, PQ H3T 1E2, Canada
推荐引用方式
GB/T 7714		 Zhang, Hua,Han, Ying-Shan,Wainberg, Mark A.,et al. Anti-HIV Securinega alkaloid oligomers from Flueggea virosa[J]. TETRAHEDRON,2015,71(22):3671-3679.
APA Zhang, Hua,Han, Ying-Shan,Wainberg, Mark A.,&Yue, Jian-Min.(2015).Anti-HIV Securinega alkaloid oligomers from Flueggea virosa.TETRAHEDRON,71(22),3671-3679.
MLA Zhang, Hua,et al."Anti-HIV Securinega alkaloid oligomers from Flueggea virosa".TETRAHEDRON 71.22(2015):3671-3679.

入库方式： OAI收割

来源：上海药物研究所

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