Limonoids with Anti-HIV Activity from Cipadessa cinerascens
文献类型：期刊论文
| 作者 | Yu, Jin-Hai1; Wang, Guo-Cai1; Han, Ying-Shan2; Wu, Yan1; Wainberg, Mark A.2; Yue, Jian-Min1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2015-06 |
| 卷号 | 78期号:6页码:1243-1252 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.5b00025 |
| 文献子类 | Article |
| 英文摘要 | Sixteen new limonoids, named ciparasins A-P (1-16), comprising three Structural categories of trijugin-type (1-7), cipadesin-type and prieurianin-type (16) compounds, as well as 15 known limonoid analogues (17-31), were isolated from Cipadessa cinerascens. Ciparasins E-G (5-7) were found to possess a rare gamma-hydroxylbutenolide moiety at C-17. Ciparasins 13 (2) and P (16) showed significant anti-HIV activities, with EC50 values of 5.5 +/- 0.6 (Si >7.2) and 6.1 +/- 0.7 (SI > 6.5) mu M, respectively. |
| WOS关键词 | TRIJUGIN-TYPE LIMONOIDS ; BACCIFERA ; LEAVES ; TETRANORTRITERPENOIDS |
| 资助项目 | National Natural Science Foundation[81273398] ; Ministry of Science and Technology of the People's Republic of China[2012CB721105] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000357138300008 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276502]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.McGill Univ, Jewish Gen Hosp, AIDS Ctr, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada |
| 推荐引用方式 GB/T 7714 | Yu, Jin-Hai,Wang, Guo-Cai,Han, Ying-Shan,et al. Limonoids with Anti-HIV Activity from Cipadessa cinerascens[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(6):1243-1252. |
| APA | Yu, Jin-Hai,Wang, Guo-Cai,Han, Ying-Shan,Wu, Yan,Wainberg, Mark A.,&Yue, Jian-Min.(2015).Limonoids with Anti-HIV Activity from Cipadessa cinerascens.JOURNAL OF NATURAL PRODUCTS,78(6),1243-1252. |
| MLA | Yu, Jin-Hai,et al."Limonoids with Anti-HIV Activity from Cipadessa cinerascens".JOURNAL OF NATURAL PRODUCTS 78.6(2015):1243-1252. |
入库方式： OAI收割
来源：上海药物研究所
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