Acidic rearrangement of benzyl group in flavone benzyl ethers and its regioselectivity
文献类型：期刊论文
| 作者 | Wang, Chong-Qing2; Chen, Xin3; Jiang, Jun-Hang2; Tang, Hui1; Zhu, Kong-Kai4; Zhou, You-Jun2; Zheng, Can-Hui2; Zhu, Ju2 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2015-06 |
| 卷号 | 26期号:6页码:793-796 |
| 关键词 | Benzyl-substituted flavone Acidic rearrangement of benzyl group Regioselectivity Quantum chemical calculation |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2015.03.035 |
| 文献子类 | Article |
| 英文摘要 | The benzyl-substituted flavone compounds are rare in nature, while some of which have interesting biological activities. The total synthesis of benzyl-substituted flavone derivatives via the acidic rearrangement of benzyl groups in flavone benzyl ethers, and the complicated regioselectivity of the rearrangement were reported. The regioselectivity was proposed to be determined by the steric hindrance as well as the ease of electrophilic substitution reaction for benzyl cations at different positions of corresponding debenzylated flavone compounds. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| WOS关键词 | INHIBITORS ; CHEMISTRY ; SITE |
| 资助项目 | National Natural Science Foundation of China[21172260] ; National Natural Science Foundation of China[30901859] ; Shanghai Natural Science Foundation[09ZR1438800] ; "Chen Guang" project - Shanghai Municipal Education Commission[00000000] ; Shanghai Education Development Foundation[12CG42] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5464378 |
| WOS记录号 | WOS:000357224900035 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276505]  |
| 专题 | 药物发现与设计中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhou, You-Jun |
| 作者单位 | 1.Shandong Univ, Prov Hosp, Pharm, Jinan 250021, Peoples R China; 2.Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China; 3.Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Chong-Qing,Chen, Xin,Jiang, Jun-Hang,et al. Acidic rearrangement of benzyl group in flavone benzyl ethers and its regioselectivity[J]. CHINESE CHEMICAL LETTERS,2015,26(6):793-796. |
| APA | Wang, Chong-Qing.,Chen, Xin.,Jiang, Jun-Hang.,Tang, Hui.,Zhu, Kong-Kai.,...&Zhu, Ju.(2015).Acidic rearrangement of benzyl group in flavone benzyl ethers and its regioselectivity.CHINESE CHEMICAL LETTERS,26(6),793-796. |
| MLA | Wang, Chong-Qing,et al."Acidic rearrangement of benzyl group in flavone benzyl ethers and its regioselectivity".CHINESE CHEMICAL LETTERS 26.6(2015):793-796. |
入库方式： OAI收割
来源：上海药物研究所
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