A One-Pot Copper(II)-Catalyzed Tandem Synthesis of 2-Substituted Pyrrolo[1,2-b]pyridazin-4(1H)-ones
文献类型：期刊论文
| 作者 | Tan, Cun; Xiang, Haoyue; He, Qian ; Yang, Chunhao
|
| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2015-06 |
| 期号 | 17页码:3656-3660 |
| 关键词 | Synthetic methods Tandem reactions Nitrogen heterocycles Pyrroles Pyridazines |
| ISSN号 | 1434-193X |
| DOI | 10.1002/ejoc.201500422 |
| 文献子类 | Article |
| 英文摘要 | A one-pot copper(II)-catalyzed tandem synthesis of 2-substituted pyrrolo[1,2-b] pyridazin-4(1H)-ones from N-aminopyrroles was developed. This tandem reaction involves a Conrad-Limpach-type reaction, including the thermal condensation of N-aminopyrroles with the carbonyl group of beta-oxo esters followed by the cyclization of Schiff base intermediates. Compared to the traditional Conrad-Limpach quinoline synthesis, we herein successfully applied copper(II) as a catalyst in this transformation to furnish 2-substituted pyrrolo[ 1,2-b] pyridazin-4(1H)-ones for the first time. Most of the substrates bearing electron-donating (EDG) and electron-withdrawing (EWG) groups worked well with this procedure. The corresponding products could be converted directly into diverse pyrrolo[1,2-b] pyridazine for drug discovery and materials science. |
| WOS关键词 | BLUE ORGANIC LUMINOPHORS ; PYRROLOPYRIDAZINE DERIVATIVES ; INHIBITORS ; DISCOVERY ; IDENTIFICATION ; ANTAGONISTS |
| 资助项目 | Chinese Academy of Sciences ("Interdisciplinary Cooperation Team" Program for Science and Technology Innovation)[00000000] ; National Natural Science Foundation of China[81321092] ; National Natural Science Foundation of China[21072205] ; State Key Laboratory of Drug Research/Shanghai Institute of Materia Medica (SKLDR/SIMM)[SIMM1403ZZ-01] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000355534600003 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276512]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Chunhao |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Cun,Xiang, Haoyue,He, Qian,et al. A One-Pot Copper(II)-Catalyzed Tandem Synthesis of 2-Substituted Pyrrolo[1,2-b]pyridazin-4(1H)-ones[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2015(17):3656-3660. |
| APA | Tan, Cun,Xiang, Haoyue,He, Qian,&Yang, Chunhao.(2015).A One-Pot Copper(II)-Catalyzed Tandem Synthesis of 2-Substituted Pyrrolo[1,2-b]pyridazin-4(1H)-ones.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(17),3656-3660. |
| MLA | Tan, Cun,et al."A One-Pot Copper(II)-Catalyzed Tandem Synthesis of 2-Substituted Pyrrolo[1,2-b]pyridazin-4(1H)-ones".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .17(2015):3656-3660. |
入库方式： OAI收割
来源：上海药物研究所
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