Tumor-Penetrating Nanotherapeutics Loading a Near-Infrared Probe Inhibit Growth and Metastasis of Breast Cancer
文献类型：期刊论文
| 作者 | He, Xinyu1,2; Bao, Xiaoyue; Cao, Haiqiang; Zhang, Zhiwen ; Yin, Qi; Gu, Wangwen; Chen, Lingli; Yu, Haijun; Li, Yaping
|
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2015-05-20 |
| 卷号 | 25期号:19页码:2831-2839 |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201500772 |
| 文献子类 | Article |
| 英文摘要 | The tumor growth and metastasis is the leading reason for the high mortality of breast cancer. Herein, it is first reported a deep tumor-penetrating photothermal nanotherapeutics loading a near-infrared (NIR) probe for potential photothermal therapy (PTT) of tumor growth and metastasis of breast cancer. The NIR probe of 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DiR), a lipophilicfluorescent carbocyanine dye with strong light-absorbing capability, is entrapped into the photothermal nanotherapeutics for PTT application. The DiR-loaded photothermal nanotherapeutics (DPN) is homogeneous nanometer-sized particles with the mean diameter of 24.5 +/- 4.1 nm. Upon 808 nm laser irradiation, DPN presents superior production of thermal energy than free DiR both in vitro and in vivo. The cell proliferation and migration activities of metastatic 4T1 breast cancer cells are obviously inhibited by DPN in combination with NIR irradiation. Moreover, DPN can induce a higher accumulation in tumor and penetrate into the deep interior of tumor tissues. The in vivo PTT measurements indicate that the growth and metastasis of breast cancer are entirely inhibited by a single treatment of DPN with NIR irradiation. Therefore, the deep tumor-penetrating DPN can provide a promising strategy for PTT of tumor progression and metastasis of breast cancer. |
| WOS关键词 | NANOPARTICLE DELIVERY-SYSTEM ; GUIDED PHOTOTHERMAL THERAPY ; IN-VIVO ; DRUG-DELIVERY ; COMBINATION THERAPY ; DEEP PENETRATION ; NANOMATERIALS ; CHEMOTHERAPY ; TOXICITY ; SIZE |
| 资助项目 | National Basic Research Program of China[2015CB932103] ; National Basic Research Program of China[2013CB932503] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81373359] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000354626800005 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276522]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | He, Xinyu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Xinyu,Bao, Xiaoyue,Cao, Haiqiang,et al. Tumor-Penetrating Nanotherapeutics Loading a Near-Infrared Probe Inhibit Growth and Metastasis of Breast Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2015,25(19):2831-2839. |
| APA | He, Xinyu.,Bao, Xiaoyue.,Cao, Haiqiang.,Zhang, Zhiwen.,Yin, Qi.,...&Li, Yaping.(2015).Tumor-Penetrating Nanotherapeutics Loading a Near-Infrared Probe Inhibit Growth and Metastasis of Breast Cancer.ADVANCED FUNCTIONAL MATERIALS,25(19),2831-2839. |
| MLA | He, Xinyu,et al."Tumor-Penetrating Nanotherapeutics Loading a Near-Infrared Probe Inhibit Growth and Metastasis of Breast Cancer".ADVANCED FUNCTIONAL MATERIALS 25.19(2015):2831-2839. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。