Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage
文献类型：期刊论文
| 作者 | Deng, Si-Si4; Zhang, Chao1,5; Wang, Huan2,3,4; Zang, Yi4 ; Li, Jia4; He, Xiao-Peng2,3; Chen, Guo-Rong2,3
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| 刊名 | CARBOHYDRATE RESEARCH
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| 出版日期 | 2015-05-18 |
| 卷号 | 408页码:114-118 |
| 关键词 | Multiple myeloma Glycolipid Anomer Synergism Apoptosis |
| ISSN号 | 0008-6215 |
| DOI | 10.1016/j.carres.2014.11.016 |
| 文献子类 | Article |
| 英文摘要 | This study describes an interesting observation that the mixture of anomeric galactolipids has synergistic effects on the growth inhibition of human multiple myeloma (MM) cells. We determine that the equivalent mixture of a pair of alpha- and beta-galactolipids with a 14-carbon lipid chain can cause stronger poly ADP-ribose polymerase cleavage and DNA damage, producing more late apoptotic MM cells, than either anomer alone. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS关键词 | CLICK CHEMISTRY ; COMBINATION THERAPY ; POLYMERASE-ACTIVITY ; INHIBITORS ; PROTEIN ; GLYCOLIPIDS ; CANCER ; ASSESSMENTS ; SPINACH |
| 资助项目 | 973 project[2013CB733700] ; National Science Fund for Distinguished Young Scholars[81125023] ; National Natural Science Foundation of China[00000000] ; Chinese Academy of Science "strategic leader in science and technology projects"[XDA01040303] ; Program of Shanghai Subject Chief Scientist[13XD1404300] ; Key Project of Shanghai Science and Technology Commission[13NM1400900] ; Fundamental Research Funds for Central Universities[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000353824500011 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276525]  |
| 专题 | 国家新药筛选中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zang, Yi |
| 作者单位 | 1.Jinan Childrens Hosp, Pediat Intens Care Unit, Jinan 250022, Shandong, Peoples R China; 2.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; 3.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 5.Shandong Univ, Jinan 250012, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Si-Si,Zhang, Chao,Wang, Huan,et al. Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage[J]. CARBOHYDRATE RESEARCH,2015,408:114-118. |
| APA | Deng, Si-Si.,Zhang, Chao.,Wang, Huan.,Zang, Yi.,Li, Jia.,...&Chen, Guo-Rong.(2015).Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage.CARBOHYDRATE RESEARCH,408,114-118. |
| MLA | Deng, Si-Si,et al."Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage".CARBOHYDRATE RESEARCH 408(2015):114-118. |
入库方式： OAI收割
来源：上海药物研究所
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