Hydrophobic interaction mediating self-assembled nanoparticles of succinobucol suppress lung metastasis of breast cancer by inhibition of VCAM-1 expression
文献类型：期刊论文
| 作者 | Cao, Haiqiang1,2; Zhang, Zhiwen1,2 ; Zhao, Shuang1,2,3; He, Xinyu1,2; Yu, Haijun1,2; Yin, Qi1,2; Zhang, Zhiping3; Gu, Wangwen1,2; Chen, Lingli1,2; Li, Yaping1,2
|
| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2015-05-10 |
| 卷号 | 205页码:162-171 |
| 关键词 | Nanoparticles Succinobucol Cancer metastasis VCAM-1 Oral delivery Breast cancer |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2015.01.015 |
| 文献子类 | Article; Proceedings Paper |
| 英文摘要 | The prevention and treatment of lung metastasis of breast cancer remain a major challenge. The vascular cell adhesion molecule-1 (VCAM-1) could provide a potential therapeutic target in lung metastasis. Herein, succinobucol (SCB), a water-insoluble potent and selective VCAM-1 inhibitor, was assembled with triblock polymer poloxamer P188 into nanoparticles due to the intermolecular hydrophobic interactions. The experimental results showed that the SCB loaded nanoparticles (SN) could greatly improve the oral delivery and suppress the lung metastasis of breast cancer. The cell migration and invasion abilities of metastatic 4T1 breast cancer cells were obviously inhibited by SN. Moreover, the VCAM-1 expression on 4T1 cells was significantly reduced by SN, and the cell-cell binding ratio of RAW264.7 cells to 4T1 cells greatly decreased from 47.4% to 3.2%. Furthermore, the oral bioavailability of SCB was greatly improved about 13-fold by SN, and the biodistribution in major organs was evidently enhanced. In particular, in the metastatic breast cancer model, the lung metastasis was notably reduced by SN treatment, and the VCAM-1 expression in lung tissues was significantly inhibited. Thereby, SN could evoke a new effective therapeutic efficacy of SCB on lung metastasis of breast cancer by inhibition of VCAM-1 expression. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS关键词 | ORAL DELIVERY ; DRUG-DELIVERY ; CELL-MIGRATION ; IMPROVES ; TUMOR ; BONE ; NANOCARRIERS ; ANTIOXIDANT ; AGI-1067 ; GENES |
| 资助项目 | National Basic Research Program of China[2015CB932103] ; National Basic Research Program of China[2013CB932503] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81373359] ; Shanghai program[12nm0501300] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000352966200019 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276533]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Zhiping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Huazhong Univ Sci & Technol, Tongji Sch Pharm, Wuhan 430030, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Haiqiang,Zhang, Zhiwen,Zhao, Shuang,et al. Hydrophobic interaction mediating self-assembled nanoparticles of succinobucol suppress lung metastasis of breast cancer by inhibition of VCAM-1 expression[J]. JOURNAL OF CONTROLLED RELEASE,2015,205:162-171. |
| APA | Cao, Haiqiang.,Zhang, Zhiwen.,Zhao, Shuang.,He, Xinyu.,Yu, Haijun.,...&Li, Yaping.(2015).Hydrophobic interaction mediating self-assembled nanoparticles of succinobucol suppress lung metastasis of breast cancer by inhibition of VCAM-1 expression.JOURNAL OF CONTROLLED RELEASE,205,162-171. |
| MLA | Cao, Haiqiang,et al."Hydrophobic interaction mediating self-assembled nanoparticles of succinobucol suppress lung metastasis of breast cancer by inhibition of VCAM-1 expression".JOURNAL OF CONTROLLED RELEASE 205(2015):162-171. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。