pH- and NIR Light-Responsive Micelles with Hyperthermia-Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer
文献类型：期刊论文
| 作者 | Yu, Haijun2,3 ; Cui, Zhirui2,3,4; Yu, Pengcheng1,2,3; Guo, Chengyue2,3; Feng, Bing2,3; Jiang, Tongying4; Wang, Siling4; Yin, Qi2,3; Zhong, Dafang2,5; Yang, Xiangliang1
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| 刊名 | ADVANCED FUNCTIONAL MATERIALS
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| 出版日期 | 2015-05-06 |
| 卷号 | 25期号:17页码:2489-2500 |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201404484 |
| 文献子类 | Article |
| 英文摘要 | The acquisition of multidrug resistance (MDR) is a major hurdle for the successful chemotherapy of tumors. Herein, a novel hybrid micelle with pH and near-infrared (NIR) light dual-responsive property is reported for reversing doxorubicin (DOX) resistance in breast cancer. The hybrid micelles are designed to integrate the pH-and NIR light-responsive property of an amphiphilic diblock polymer and the high DOX loading capacity of a polymeric prodrug into one single nanocomposite. At physiological condition (i.e., pH 7.4), the micelles form compact nanostructure with particle size around 30 nm to facilitate blood circulation and passive tumor targeting. Meanwhile, the micelles are quickly dissociated in weakly acidic environment (i.e., pH <= 6.2) to release DOX prodrug. When exposed to NIR laser irradiation, the hybrid micelles can trigger notable tumor penetration and cytosol release of DOX payload by inducing tunable hyperthermia effect. In combination with localized NIR laser irradiation, the hybrid micelles significantly inhibit the growth of DOX-resistant MCF-7/ADR breast cancer in an orthotopic tumor bearing mouse model. Taken together, this pH and NIR light-responsive micelles with hyperthermia-triggered tumor penetration and cytoplasm drug release can be an effective nanoplatform to combat cancer MDR. |
| WOS关键词 | MULTIDRUG-RESISTANCE ; CO-DELIVERY ; LUNG-CANCER ; NANOPARTICLES ; CELLS ; SIRNA ; CHEMOTHERAPY ; THERAPY ; THERAPEUTICS ; ACCUMULATION |
| 资助项目 | National Basic Research Program of China[2013CB932704] ; National Basic Research Program of China[2012CB932502] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81373359] ; SA-SIBS Scholarship Program[00000000] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000354200000001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276535]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yu, Haijun |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Natl Engn Res Ctr Nanomed, Wuhan 430074, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China; 4.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Metab, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Haijun,Cui, Zhirui,Yu, Pengcheng,et al. pH- and NIR Light-Responsive Micelles with Hyperthermia-Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2015,25(17):2489-2500. |
| APA | Yu, Haijun.,Cui, Zhirui.,Yu, Pengcheng.,Guo, Chengyue.,Feng, Bing.,...&Li, Yaping.(2015).pH- and NIR Light-Responsive Micelles with Hyperthermia-Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer.ADVANCED FUNCTIONAL MATERIALS,25(17),2489-2500. |
| MLA | Yu, Haijun,et al."pH- and NIR Light-Responsive Micelles with Hyperthermia-Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer".ADVANCED FUNCTIONAL MATERIALS 25.17(2015):2489-2500. |
入库方式： OAI收割
来源：上海药物研究所
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