The role of the GABA system in amphetamine-type stimulant use disorders
文献类型：期刊论文
| 作者 | Jiao, Dongliang1; Liu, Yao1; Li, Xiaohong2; Liu, Jinggen3 ; Zhao, Min1
|
| 刊名 | FRONTIERS IN CELLULAR NEUROSCIENCE
 |
| 出版日期 | 2015-05-05 |
| 卷号 | 9 |
| 关键词 | GABA system amphetamine-type stimulants use disorders psychotic cognitive dysfunctions drug abuse |
| ISSN号 | 1662-5102 |
| DOI | 10.3389/fncel.2015.00162 |
| 文献子类 | Review |
| 英文摘要 | Abuse of amphetamine-type stimulants (ATS) has become a global public health problem. ATS causes severe neurotoxicity, which could lead to addiction and could induce psychotic disorders or cognitive dysfunctions. However, until now, there has been a lack of effective medicines for treating ATS-related problems. Findings from recent studies indicate that in addition to the traditional dopamine-ergic system, the GABA (gamma-aminobutyric acid)-ergic system plays an important role in ATS abuse. However, the exact mechanisms of the GABA-ergic system in amphetamine-type stimulant use disorders are not fully understood. This review discusses the role of the GABA-ergic system in ATS use disorders, including ATS induced psychotic disorders and cognitive dysfunctions. We conclude that the GABA-ergic system are importantly involved in the development of ATS use disorders through multiple pathways, and that therapies or medicines that target specific members of the GABA-ergic system may be novel effective interventions for the treatment of ATS use disorders. |
| WOS关键词 | VENTRAL TEGMENTAL AREA ; INDUCED BEHAVIORAL SENSITIZATION ; CONDITIONED PLACE PREFERENCE ; METHAMPHETAMINE USE DISORDER ; NUCLEUS-ACCUMBENS ; PREFRONTAL CORTEX ; LOCOMOTOR-ACTIVITY ; DRUG-ADDICTION ; BASAL GANGLIA ; GABAERGIC INTERNEURONS |
| 资助项目 | Chinese National Nature Science Foundation[81271468] ; Chinese National Nature Science Foundation[81130020] ; Ministry of Education[20120073110089] ; Shanghai city health and family planning committee[2014ZYJB0002] ; Shanghai Key Laboratory of Severe Mental illness[13dz2260500] ; China Postdoctoral Science Foundation[2014M561482] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000354801600001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276538]  |
| 专题 | 药理学第二研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Zhao, Min |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai 200030, Peoples R China; 2.NY State Inst Basic Res Dev Disabilities, Dept Neurochem, New York, NY USA; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiao, Dongliang,Liu, Yao,Li, Xiaohong,et al. The role of the GABA system in amphetamine-type stimulant use disorders[J]. FRONTIERS IN CELLULAR NEUROSCIENCE,2015,9. |
| APA | Jiao, Dongliang,Liu, Yao,Li, Xiaohong,Liu, Jinggen,&Zhao, Min.(2015).The role of the GABA system in amphetamine-type stimulant use disorders.FRONTIERS IN CELLULAR NEUROSCIENCE,9. |
| MLA | Jiao, Dongliang,et al."The role of the GABA system in amphetamine-type stimulant use disorders".FRONTIERS IN CELLULAR NEUROSCIENCE 9(2015). |
入库方式： OAI收割
来源：上海药物研究所
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