Phosphine-Catalyzed Aza-MBH Reactions of Vinylpyridines: Efficient and Rapid Access to 2,3,5-Triarylsubstituted 3-Pyrrolines
文献类型：期刊论文
| 作者 | Chen, Jing2 ; Li, Jianjun1; Wang, Jiazhe1; Li, Hao1; Wang, Wei1,3; Guo, Yuewei2
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2015-05-01 |
| 卷号 | 17期号:9页码:2214-2217 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.5b00811 |
| 文献子类 | Article |
| 英文摘要 | Vinylpyridines have been developed in,aza-Morita-Baylis-Hiliman (MBH) reaction to construct triarylsubstituted 3-pyrrolines. The first electron deficient,aromatic ring is marked as an activating mode for the vinyl group in the MBH reaction. This method provides efficient and rapid access to a range of triarylpyrrolines in good yields and at an excellent level of diastereoselectivity. Moreover, the synthetic potential of this protocol is further enhanced by the straightforward synthesis of unsymmetrical tri- and polyarylsubstituted pyrroles. |
| WOS关键词 | BAYLIS-HILLMAN REACTION ; AGGREGATION-INDUCED EMISSION ; SYNTHETIC APPLICATIONS ; ALLYLIC SUBSTITUTION ; HILIMAN REACTION ; ALKALOIDS ; IMINES ; PYRROLES ; ACID ; DERIVATIVES |
| 资助项目 | National Marine "863" Projects[2013AA092902] ; NSFC-Shangdong Joint Fund for Marine Science Research Centers[U1406402] ; program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning[201226] ; National Science Foundation of China[21372073] ; East China University of Science and Technology[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000354004400045 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276546]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物安全性评价中心 |
| 通讯作者 | Li, Hao |
| 作者单位 | 1.E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 3.Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA |
| 推荐引用方式 GB/T 7714 | Chen, Jing,Li, Jianjun,Wang, Jiazhe,et al. Phosphine-Catalyzed Aza-MBH Reactions of Vinylpyridines: Efficient and Rapid Access to 2,3,5-Triarylsubstituted 3-Pyrrolines[J]. ORGANIC LETTERS,2015,17(9):2214-2217. |
| APA | Chen, Jing,Li, Jianjun,Wang, Jiazhe,Li, Hao,Wang, Wei,&Guo, Yuewei.(2015).Phosphine-Catalyzed Aza-MBH Reactions of Vinylpyridines: Efficient and Rapid Access to 2,3,5-Triarylsubstituted 3-Pyrrolines.ORGANIC LETTERS,17(9),2214-2217. |
| MLA | Chen, Jing,et al."Phosphine-Catalyzed Aza-MBH Reactions of Vinylpyridines: Efficient and Rapid Access to 2,3,5-Triarylsubstituted 3-Pyrrolines".ORGANIC LETTERS 17.9(2015):2214-2217. |
入库方式： OAI收割
来源：上海药物研究所
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