Biological stimuli-responsive cyclodextrin-based host-guest nanosystems for cancer therapy
文献类型：期刊论文
| 作者 | Dan, Zhaoling2; Cao, Haiqiang1,3; He, Xinyu1,3; Zeng, Lijuan1,3; Zou, Lili2; Shen, Qi2; Zhang, Zhiwen1,3
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| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2015-04-10 |
| 卷号 | 483期号:1-2页码:63-68 |
| 关键词 | Stimuli-responsive Cyclodextrin Host-guest Nanosystem Drug delivery Cancer therapy |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2015.01.035 |
| 文献子类 | Review |
| 英文摘要 | Stimuli-responsive nanosystems are of particular interest in cancer therapy, owing to their impressive capability to enable the on-demand drug release in response to specific biological stimuli in tumor microenvironments (such as pH, redox and enzyme, etc.). Cyclodextrin (CD)-based host-guest interactions provide a flexible and powerful platform for the development of multifunctional nanosystems. This article highlights the current progress of CD-based host-guest nanosystems (CHNs) with biological stimuli-responsive properties in cancer therapy. We summarize the composition, structure and design of various CHNs in response to specific stimuli in tumor, and focus on their performance in controlled drug delivery and cancer therapy. These recent advances make it a promising and intelligent drug delivery system to improve the anticancer efficacy. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS关键词 | MESOPOROUS SILICA NANOPARTICLES ; DRUG-DELIVERY ; BETA-CYCLODEXTRIN ; IN-VITRO ; CONTROLLED-RELEASE ; BIOMEDICAL APPLICATIONS ; PH ; SYSTEM ; TUMOR ; GENE |
| 资助项目 | National Basic Research Program of China[2015CB932103] ; National Basic Research Program of China[2013CB932503] ; National Natural Science Foundation of China[81270047] ; National Natural Science Foundation of China[81373359] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000350454200008 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276574]  |
| 专题 | 药物制剂研究中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Dan, Zhaoling |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dan, Zhaoling,Cao, Haiqiang,He, Xinyu,et al. Biological stimuli-responsive cyclodextrin-based host-guest nanosystems for cancer therapy[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2015,483(1-2):63-68. |
| APA | Dan, Zhaoling.,Cao, Haiqiang.,He, Xinyu.,Zeng, Lijuan.,Zou, Lili.,...&Zhang, Zhiwen.(2015).Biological stimuli-responsive cyclodextrin-based host-guest nanosystems for cancer therapy.INTERNATIONAL JOURNAL OF PHARMACEUTICS,483(1-2),63-68. |
| MLA | Dan, Zhaoling,et al."Biological stimuli-responsive cyclodextrin-based host-guest nanosystems for cancer therapy".INTERNATIONAL JOURNAL OF PHARMACEUTICS 483.1-2(2015):63-68. |
入库方式： OAI收割
来源：上海药物研究所
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