Dicarabrones A and B, a Pair of New Epimers Dimerized from Sesquiterpene Lactones via a [3+2] Cycloaddition from Carpesium abrotanoides
文献类型：期刊论文
| 作者 | Wu, Jiewei2,5; Tang, Chunping2,5 ; Chen, Lan1; Qiao, Yan3; Geng, Meiyu1; Ye, Yang2,4,5
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2015-04-03 |
| 卷号 | 17期号:7页码:1656-1659 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.5b00371 |
| 文献子类 | Article |
| 英文摘要 | Dicarabrones A and B, a pair of epimers possessing a new skeleton featuring a cyclopentane ring connecting two sesquiterpene lactone units, were isolated from the whole plant of Carpesium abrotanoides L. Their full structures were established on the basis of spectroscopic data and were further confirmed by single-crystal X-ray crystallography. They were presumably biosynthesized from two sesquiterpenoid monomers through a [3 + 2] cycloaddition. Dicarabrones A and B showed moderate effects on HL-60 cells with IC50 values of 9.1 and 8.2 mu M, respectively. |
| WOS关键词 | DONOR-ACCEPTOR CYCLOPROPANES ; CROSS-CYCLOADDITION ; NONCOVALENT INTERACTIONS ; THERMOCHEMICAL KINETICS ; DENSITY FUNCTIONALS ; CONSTRUCTION ; SKELETONS ; 1,1-DIESTERS ; CARBONYLS ; STRATEGY |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2011ZX09307-002-03] ; National Natural Science Funds for Distinguished Young Scholar[30925043] ; Ministry of Science and Technology[2007DFC31030] ; Ministry of Science and Technology[2010DFA30980] ; Shanghai Commission of Science and Technology[10DZ1972700] ; Shanghai Commission of Science and Technology[11DZ1970700] ; Shanghai Commission of Science and Technology[12JC1410300] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000352463200010 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276576]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Ye, Yang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Oncol Pharmacol, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, SIMM CUHK Joint Res Lab Promoting Globalizat Trad, Shanghai 201203, Peoples R China; 3.Zhengzhou Univ, Sch Basic Med Sci, Dept Pathophysiol, Zhengzhou 450001, Henan, Peoples R China; 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wu, Jiewei,Tang, Chunping,Chen, Lan,et al. Dicarabrones A and B, a Pair of New Epimers Dimerized from Sesquiterpene Lactones via a [3+2] Cycloaddition from Carpesium abrotanoides[J]. ORGANIC LETTERS,2015,17(7):1656-1659. |
| APA | Wu, Jiewei,Tang, Chunping,Chen, Lan,Qiao, Yan,Geng, Meiyu,&Ye, Yang.(2015).Dicarabrones A and B, a Pair of New Epimers Dimerized from Sesquiterpene Lactones via a [3+2] Cycloaddition from Carpesium abrotanoides.ORGANIC LETTERS,17(7),1656-1659. |
| MLA | Wu, Jiewei,et al."Dicarabrones A and B, a Pair of New Epimers Dimerized from Sesquiterpene Lactones via a [3+2] Cycloaddition from Carpesium abrotanoides".ORGANIC LETTERS 17.7(2015):1656-1659. |
入库方式： OAI收割
来源：上海药物研究所
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