A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects
文献类型：期刊论文
| 作者 | Ruan, Zhi1; Wang, Hong Min2; Huang, Xiao Tian1; Fu, Yan1; Wu, Jian2; Ye, Chun Yan1; Li, Jin Long2; Wu, Lei1; Gong, Qi1; Zhao, Wei Min2 |
| 刊名 | JOURNAL OF NEUROCHEMISTRY
 |
| 出版日期 | 2015-04 |
| 卷号 | 133期号:1页码:93-103 |
| 关键词 | caffeoyl triterpene hypothermia inflammation ischemic stroke neuroprotection therapeutic time window |
| ISSN号 | 0022-3042 |
| DOI | 10.1111/jnc.13046 |
| 文献子类 | Article |
| 英文摘要 | Despite the intense efforts in searching for stroke therapies, an urgent need still exists to explore novel neuroprotective agents for ischemic stroke that have high efficacy and wide therapeutic time-window. Here, we provide the first demonstration that 28-O-caffeoyl betulin (B-CA), a novel derivative of naturally occurring caffeoyl triterpene, could significantly alleviate brain infarction and neurological deficit when given as late as 6h after transient middle cerebral artery occlusion in the rat. Moreover, post-ischemia B-CA administration exhibited long-term (14days post stroke) protective effects on both brain infarction and functional (i.e., motor and sensory) deficits. Protective B-CA effects correlated with decreased inflammatory responses as indicated by inhibition of microglia and astrocyte activation [stained with ionized calcium-binding adapter molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) antibody, respectively], as well as suppression of tumor necrosis factor-, interleukin-1, and cyclooxygenase-2 overproduction in the ipsilateral cortex of ischemic rat. B-CA administration caused significant hypothermia in the focal cerebral ischemic rat, which may contribute to its ameliorative effects on brain damage and inflammation. In view of its potency in wide therapeutic time-window, robust anti-inflammatory and hypothermic effects, this novel caffeoyl triterpene derivative may lead toward the development of effective therapeutic strategies for the treatment of ischemic stroke. |
| WOS关键词 | VANILLOID RECEPTOR TRPV1 ; BRAIN INFLAMMATION ; NEUROVASCULAR PROTECTION ; EXPERIMENTAL STROKE ; BODY-TEMPERATURE ; ARTERY OCCLUSION ; NATURAL-PRODUCTS ; DRUG DISCOVERY ; EXPRESSION ; RATS |
| 资助项目 | Ministry of Science and Technology of China[2011CB510004] ; National Natural Science Foundation of China[81173034] ; National Natural Science Foundation of China[81473113] ; National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program' of China[2012ZX09301001-004] ; State Key Laboratory of Drug Research[SIMM1403KF-04] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000351393900009 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276592]  |
| 专题 | 天然药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药理学第二研究室 |
| 通讯作者 | Zhang, Hai Yan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, CAS Key Lab Receptor Res, Shanghai 200031, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ruan, Zhi,Wang, Hong Min,Huang, Xiao Tian,et al. A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects[J]. JOURNAL OF NEUROCHEMISTRY,2015,133(1):93-103. |
| APA | Ruan, Zhi.,Wang, Hong Min.,Huang, Xiao Tian.,Fu, Yan.,Wu, Jian.,...&Zhang, Hai Yan.(2015).A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects.JOURNAL OF NEUROCHEMISTRY,133(1),93-103. |
| MLA | Ruan, Zhi,et al."A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects".JOURNAL OF NEUROCHEMISTRY 133.1(2015):93-103. |
入库方式： OAI收割
来源：上海药物研究所
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