Asymmetric Total Synthesis of (+)-Dragmacidin D Reveals Unexpected Stereocomplexity
文献类型：期刊论文
| 作者 | Zhang, Fengying1; Wang, Bin1; Prasad, Pritesh3; Capon, Robert J.3; Jia, Yanxing1,2 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2015-03-20 |
| 卷号 | 17期号:6页码:1529-1532 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.5b00327 |
| 文献子类 | Article |
| 英文摘要 | The first asymmetric total synthesis of the bis-indole marine alkaloid (+)-dragmacidin D (1) has been achieved. This synthesis revises an earlier configurational assignment based on biosynthetic considerations and assigns an R absolute configuration to (+)-1. The current studies reveal that natural dragmacidin D is isolated as either a racemate or a scalemic mixture (39% ee). |
| WOS关键词 | CYCLOHEPTANNELATED INDOLE FRAGMENT ; ENANTIOSELECTIVE TOTAL-SYNTHESIS ; EFFICIENT TOTAL-SYNTHESIS ; DRAGMACIDIN-E SYNTHESIS ; WATER MARINE SPONGE ; (+)-LYSERGIC ACID ; CLAVICIPITIC ACID ; DIRECT ANNULATION ; (+/-)-SEROTOBENINE ; SPONGOSORITES |
| 资助项目 | National Natural Science Foundation of China[21290183] ; Ph.D. Programs Foundation of Ministry of Education of China[20120001110100] ; State Key Laboratory of Drug Research, the Australian Research Council[DP120100183] ; University of Queensland, Institute for Molecular Bioscience[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000351558100046 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276602]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | Capon, Robert J. |
| 作者单位 | 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia |
| 推荐引用方式 GB/T 7714 | Zhang, Fengying,Wang, Bin,Prasad, Pritesh,et al. Asymmetric Total Synthesis of (+)-Dragmacidin D Reveals Unexpected Stereocomplexity[J]. ORGANIC LETTERS,2015,17(6):1529-1532. |
| APA | Zhang, Fengying,Wang, Bin,Prasad, Pritesh,Capon, Robert J.,&Jia, Yanxing.(2015).Asymmetric Total Synthesis of (+)-Dragmacidin D Reveals Unexpected Stereocomplexity.ORGANIC LETTERS,17(6),1529-1532. |
| MLA | Zhang, Fengying,et al."Asymmetric Total Synthesis of (+)-Dragmacidin D Reveals Unexpected Stereocomplexity".ORGANIC LETTERS 17.6(2015):1529-1532. |
入库方式： OAI收割
来源：上海药物研究所
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